{"id":"5744c6fabe737e7d6f20bef6","organism":"Klebsiella pneumoniae Kp13","name":"Kp13","description":"Klebsiella pneumoniae Kp13","status":null,"ncbi_assembly":null,"auth":"563b9440b1b50423d1fd1fee","_cls":"SeqCollection.Genome","size":null,"type":"genome","has_expression":null,"goIndex":true,"ecIndex":true,"expression_samples":null,"statistics":[{"name":"druggabilityDistribution","description":null,"value":0.0,"values":[0.021289919,0.0,0.008766437,0.015028178,0.02974327,0.06355667,0.12398247,0.23638071,0.30244207,0.19881026],"labels":[]},{"name":"dp_has_structure","description":null,"value":0.0,"values":[2206.0,3194.0,336.0],"labels":["unannotated","true","false"]},{"name":"dp_structure_type","description":null,"value":0.0,"values":[2542.0,422.0,2772.0],"labels":["unannotated","experimental","model"]},{"name":"dp_druggability","description":null,"value":0.0,"values":[2542.0,68.0,0.0,28.0,48.0,95.0,203.0,396.0,755.0,966.0,635.0],"labels":["unannotated","0.0-0.1","0.1-0.2","0.2-0.3","0.3-0.4","0.4-0.49","0.49-0.59","0.59-0.69","0.69-0.79","0.79-0.89","0.89-0.99"]},{"name":"dp_hydrophobicity","description":null,"value":0.0,"values":[2303.0,27.0,32.0,46.0,66.0,114.0,203.0,447.0,663.0,979.0,856.0],"labels":["unannotated","0.21-0.28","0.28-0.36","0.36-0.44","0.44-0.52","0.52-0.6","0.6-0.68","0.68-0.75","0.75-0.83","0.83-0.91","0.91-0.99"]},{"name":"dp_volume","description":null,"value":0.0,"values":[2303.0,3225.0,164.0,22.0,8.0,9.0,0.0,0.0,0.0,0.0,5.0],"labels":["unannotated","63.51-2688.65","2688.65-5313.79","5313.79-7938.94","7938.94-10564.08","10564.08-13189.22","13189.22-15814.36","15814.36-18439.5","18439.5-21064.64","21064.64-23689.79","23689.79-26314.93"]},{"name":"dp_free_tyr","description":null,"value":0.0,"values":[2206.0,3359.0,171.0],"labels":["unannotated","true","false"]},{"name":"dp_tyr","description":null,"value":0.0,"values":[2206.0,2868.0,662.0],"labels":["unannotated","true","false"]},{"name":"dp_free_cys","description":null,"value":0.0,"values":[2206.0,2942.0,588.0],"labels":["unannotated","true","false"]},{"name":"dp_cys","description":null,"value":0.0,"values":[2206.0,2450.0,1080.0],"labels":["unannotated","true","false"]},{"name":"dp_csa","description":null,"value":0.0,"values":[2282.0,709.0,2745.0],"labels":["unannotated","true","false"]},{"name":"dp_domain_extended","description":null,"value":0.0,"values":[2282.0,2069.0,1385.0],"labels":["unannotated","true","false"]},{"name":"dp_pocket_with_free_tyr","description":null,"value":0.0,"values":[2206.0,2893.0,637.0],"labels":["unannotated","true","false"]},{"name":"dp_pocket_with_tyr","description":null,"value":0.0,"values":[2206.0,2652.0,878.0],"labels":["unannotated","true","false"]},{"name":"dp_pocket_with_free_cys","description":null,"value":0.0,"values":[2206.0,2097.0,1433.0],"labels":["unannotated","true","false"]},{"name":"dp_pocket_with_cys","description":null,"value":0.0,"values":[2206.0,1965.0,1565.0],"labels":["unannotated","true","false"]},{"name":"dp_pocket_with_csa","description":null,"value":0.0,"values":[2206.0,474.0,3056.0],"labels":["unannotated","true","false"]},{"name":"dp_pocket_with_domain_extended","description":null,"value":0.0,"values":[2206.0,2166.0,1364.0],"labels":["unannotated","true","false"]},{"name":"dp_pocket_with_pfam_imp_residue","description":null,"value":0.0,"values":[2206.0,3079.0,451.0],"labels":["unannotated","true","false"]},{"name":"dp_drug_binding","description":null,"value":0.0,"values":[2282.0,1472.0,1982.0],"labels":["unannotated","true","false"]},{"name":"dp_pocket_with_drug_binding","description":null,"value":0.0,"values":[2282.0,654.0,2800.0],"labels":["unannotated","true","false"]},{"name":"dp_lipid_binding","description":null,"value":0.0,"values":[2206.0,62.0,3468.0],"labels":["unannotated","true","false"]},{"name":"dp_pocket_with_lipid_binding","description":null,"value":0.0,"values":[2206.0,6.0,3524.0],"labels":["unannotated","true","false"]},{"name":"dp_metal_binding","description":null,"value":0.0,"values":[2206.0,5.0,3525.0],"labels":["unannotated","true","false"]},{"name":"dp_pocket_with_metal_binding","description":null,"value":0.0,"values":[2206.0,0.0,3530.0],"labels":["unannotated","true","false"]},{"name":"dp_nucleotide_binding","description":null,"value":0.0,"values":[2206.0,85.0,3445.0],"labels":["unannotated","true","false"]},{"name":"dp_pocket_with_nucleotide_binding","description":null,"value":0.0,"values":[2206.0,22.0,3508.0],"labels":["unannotated","true","false"]},{"name":"dp_sugar_binding","description":null,"value":0.0,"values":[2206.0,78.0,3452.0],"labels":["unannotated","true","false"]},{"name":"dp_pocket_with_sugar_binding","description":null,"value":0.0,"values":[2206.0,16.0,3514.0],"labels":["unannotated","true","false"]},{"name":"dp_centrality","description":null,"value":0.0,"values":[4608.0,963.0,108.0,21.0,15.0,6.0,6.0,5.0,0.0,2.0,2.0],"labels":["unannotated","0.0-0.1","0.1-0.2","0.2-0.3","0.3-0.4","0.4-0.5","0.5-0.6","0.6-0.7","0.7-0.8","0.8-0.9","0.9-1.0"]},{"name":"dp_chokepoint","description":null,"value":0.0,"values":[4535.0,824.0,377.0],"labels":["unannotated","true","false"]},{"name":"dp_chokepoint_type","description":null,"value":0.0,"values":[4895.0,576.0,47.0,218.0],"labels":["unannotated","consuming","double","production"]},{"name":"dp_reactions","description":null,"value":0.0,"values":[396.0,298.0,62.0,21.0,6.0,4.0,2.0,1.0,0.0,0.0,2.0],"labels":["unannotated","1.0","6.6","12.2","17.799999999999997","23.4","29.0","34.599999999999994","40.199999999999996","45.8","51.4","57.0"]},{"name":"dp_norm_reactions","description":null,"value":0.0,"values":[396.0,298.0,62.0,21.0,6.0,5.0,1.0,1.0,0.0,0.0,2.0],"labels":["unannotated","0.0175438596491228","0.11578947368421053","0.21403508771929824","0.312280701754386","0.4105263157894737","0.5087719298245613","0.6070175438596491","0.7052631578947368","0.8035087719298245","0.9017543859649122","1.0"]},{"name":"dp_reactions_with_gene","description":null,"value":0.0,"values":[396.0,304.0,58.0,19.0,7.0,4.0,1.0,1.0,0.0,0.0,2.0],"labels":["unannotated","1.0","6.5","12.0","17.5","23.0","28.5","34.0","39.5","45.0","50.5","56.0"]},{"name":"dp_completeness","description":null,"value":0.0,"values":[396.0,1.0,10.0,5.0,12.0,2.0,13.0,12.0,15.0,12.0,314.0],"labels":["unannotated","0.2","0.28","0.36","0.44","0.52","0.6000000000000001","0.6799999999999999","0.76","0.8400000000000001","0.9199999999999999","1.0"]},{"name":"dp_chokepoints","description":null,"value":0.0,"values":[396.0,302.0,63.0,21.0,5.0,1.0,2.0,1.0,0.0,0.0,1.0],"labels":["unannotated","0.0","5.0","10.0","15.0","20.0","25.0","30.0","35.0","40.0","45.0","50.0"]},{"name":"dp_norm_chokepoint","description":null,"value":0.0,"values":[396.0,64.0,9.0,14.0,19.0,10.0,49.0,30.0,27.0,30.0,144.0],"labels":["unannotated","0.0","0.1","0.2","0.30000000000000004","0.4","0.5","0.6000000000000001","0.7000000000000001","0.8","0.9","1.0"]},{"name":"dp_druggable","description":null,"value":0.0,"values":[396.0,370.0,26.0],"labels":["unannotated","Yes","No"]},{"name":"dp_max_centrality","description":null,"value":0.0,"values":[396.0,231.0,76.0,32.0,27.0,3.0,14.0,8.0,0.0,2.0,3.0],"labels":["unannotated","0.0","0.1","0.2","0.30000000000000004","0.4","0.5","0.6000000000000001","0.7000000000000001","0.8","0.9","1.0"]},{"name":"dp_hit_in_deg","description":null,"value":0.0,"values":[0.0,3621.0,2115.0],"labels":["unannotated","No","Yes"]},{"name":"dp_essential_in_mgh78578","description":null,"value":0.0,"values":[0.0,5632.0,104.0],"labels":["unannotated","No","Yes"]},{"name":"dp_conserved_pathogen","description":null,"value":0.0,"values":[0.0,1381.0,1378.0,955.0,754.0,466.0,366.0,263.0,130.0,36.0,7.0],"labels":["unannotated","0.0-2.1","2.1-4.2","4.2-6.3","6.3-8.4","8.4-10.5","10.5-12.6","12.6-14.7","14.7-16.8","16.8-18.9","18.9-21.0"]},{"name":"dp_conserved_pathogen_bbh","description":null,"value":0.0,"values":[520.0,935.0,1351.0,943.0,739.0,459.0,359.0,260.0,129.0,34.0,7.0],"labels":["unannotated","1.0-3.0","3.0-5.0","5.0-7.0","7.0-9.0","9.0-11.0","11.0-13.0","13.0-15.0","15.0-17.0","17.0-19.0","19.0-21.0"]},{"name":"dp_conserved_no_pathogen","description":null,"value":0.0,"values":[0.0,2824.0,0.0,116.0,0.0,0.0,111.0,0.0,2681.0,0.0,1.0],"labels":["unannotated","0.0-0.4","0.4-0.8","0.8-1.2","1.2-1.6","1.6-2.0","2.0-2.4","2.4-2.8","2.8-3.2","3.2-3.6","3.6-4.0"]},{"name":"dp_overexpressed_in_polymyxin","description":null,"value":0.0,"values":[0.0,2516.0,700.0],"labels":["unannotated","NO","YES"]},{"name":"dp_overexpressed_in_polymixin_all_conditions","description":null,"value":0.0,"values":[0.0,3064.0,152.0],"labels":["unannotated","NO","YES"]},{"name":"dp_conserved_pathogen_norm","description":null,"value":0.0,"values":[0.0,1381.0,1378.0,955.0,754.0,466.0,366.0,263.0,130.0,36.0,7.0],"labels":["unannotated","0.0-0.06","0.06-0.11","0.11-0.17","0.17-0.22","0.22-0.28","0.28-0.33","0.33-0.39","0.39-0.44","0.44-0.5","0.5-0.55"]},{"name":"dp_conserved_pathogen_bbh_norm","description":null,"value":0.0,"values":[520.0,1640.0,1163.0,822.0,593.0,209.0,494.0,200.0,78.0,15.0,2.0],"labels":["unannotated","0.03-0.08","0.08-0.13","0.13-0.18","0.18-0.24","0.24-0.29","0.29-0.34","0.34-0.39","0.39-0.45","0.45-0.5","0.5-0.55"]},{"name":"dp_conserved_no_pathogen_norm","description":null,"value":0.0,"values":[0.0,0.0,0.0,0.0,0.0,0.0,5736.0,0.0,0.0,0.0,0.0],"labels":["unannotated","-0.5--0.4","-0.4--0.3","-0.3--0.2","-0.2--0.1","-0.1-0.0","0.0-0.1","0.1-0.2","0.2-0.3","0.3-0.4","0.4-0.5"]},{"name":"dp_gut_microbiome","description":null,"value":0.0,"values":[1076.0,3132.0,660.0,250.0,140.0,126.0,66.0,70.0,77.0,51.0,88.0],"labels":["unannotated","1.0-23.5","23.5-46.0","46.0-68.5","68.5-91.0","91.0-113.5","113.5-136.0","136.0-158.5","158.5-181.0","181.0-203.5","203.5-226.0"]},{"name":"dp_gut_microbiome_norm","description":null,"value":0.0,"values":[1076.0,3132.0,660.0,250.0,140.0,126.0,66.0,70.0,77.0,51.0,88.0],"labels":["unannotated","0.0-0.1","0.1-0.2","0.2-0.3","0.3-0.4","0.4-0.5","0.5-0.6","0.6-0.7","0.7-0.8","0.8-0.9","0.9-1.0"]},{"name":"dp_human_offtarget","description":null,"value":0.0,"values":[0.0,3.0,7.0,33.0,51.0,171.0,316.0,433.0,33.0,0.0,4689.0],"labels":["unannotated","0.25-0.33","0.33-0.4","0.4-0.47","0.47-0.55","0.55-0.63","0.63-0.7","0.7-0.78","0.78-0.85","0.85-0.92","0.92-1.0"]},{"name":"dp_essentiality","description":null,"value":0.0,"values":[0.0,346.0,5390.0],"labels":["unannotated","yes","no"]},{"name":"proteins","description":null,"value":5736.0,"values":[],"labels":[]},{"name":"ec","description":null,"value":1881.0,"values":[],"labels":[]},{"name":"go","description":null,"value":3869.0,"values":[],"labels":[]},{"name":"SO:0001079","description":"polypeptide_structural_motif","value":422.0,"values":[],"labels":[]},{"name":"Models","description":"Structures generated by Homology","value":2772.0,"values":[],"labels":[]},{"name":"SO:0000417","description":"polypeptide_domain_count","value":4670.0,"values":[],"labels":[]},{"name":"SO:0000418","description":"signal_peptide_count","value":776.0,"values":[],"labels":[]},{"name":"SO:0100009","description":"lipo_signal_peptide_count","value":151.0,"values":[],"labels":[]},{"name":"SO:0001077","description":"transmembrane_count","value":1683.0,"values":[],"labels":[]}],"assembly":null,"properties":null,"publications":null,"strains":null,"strainsProps":null,"strainProjects":null,"pathways":[{"term":"PWY-4621","name":"arsenate detoxification II (glutaredoxin)","count":4,"properties2":{"reactions":3,"completeness":0.666666666666667,"reactions_with_gene":2,"genes":4,"norm_chokepoint":0.666666666666667,"druggable":"Yes","max_centrality":0.02394,"norm_reactions":0.0526315789473684,"chokepoints":2},"properties":null,"score":0.0},{"term":"PWY-5490","name":"paraoxon degradation","count":1,"properties2":{"reactions":1,"completeness":1.0,"reactions_with_gene":1,"genes":1,"norm_chokepoint":1.0,"druggable":"Yes","max_centrality":0.0,"norm_reactions":0.0175438596491228,"chokepoints":1},"properties":null,"score":0.0},{"term":"PWY-5084","name":"2-oxoglutarate decarboxylation to succinyl-CoA","count":8,"properties2":{"reactions":3,"completeness":1.0,"reactions_with_gene":3,"genes":8,"norm_chokepoint":1.0,"druggable":"Yes","max_centrality":0.0524523351246885,"norm_reactions":0.0526315789473684,"chokepoints":3},"properties":null,"score":0.0},{"term":"PYRIDOXSYN-PWY","name":"pyridoxal 5'-phosphate biosynthesis I","count":9,"properties2":{"reactions":8,"completeness":0.875,"reactions_with_gene":7,"genes":9,"norm_chokepoint":1.0,"druggable":"Yes","max_centrality":0.09873,"norm_reactions":0.140350877192982,"chokepoints":8},"properties":null,"score":0.0},{"term":"PWY-5918","name":"superpathay of heme biosynthesis from glutamate","count":10,"properties2":{"reactions":10,"completeness":1.0,"reactions_with_gene":10,"genes":10,"norm_chokepoint":0.9,"druggable":"Yes","max_centrality":0.0644,"norm_reactions":0.175438596491228,"chokepoints":9},"properties":null,"score":0.0},{"term":"PWY-7346","name":"UDP-α-D-glucuronate biosynthesis (from UDP-glucose)","count":1,"properties2":{"reactions":1,"completeness":1.0,"reactions_with_gene":1,"genes":1,"norm_chokepoint":1.0,"druggable":"Yes","max_centrality":0.02228,"norm_reactions":0.0175438596491228,"chokepoints":1},"properties":null,"score":0.0},{"term":"PWY-7344","name":"UDP-D-galactose biosynthesis","count":2,"properties2":{"reactions":1,"completeness":1.0,"reactions_with_gene":1,"genes":2,"norm_chokepoint":0.0,"druggable":"Yes","max_centrality":0.0077,"norm_reactions":0.0175438596491228,"chokepoints":0},"properties":null,"score":0.0},{"term":"ILEUSYN-PWY","name":"isoleucine biosynthesis I (from threonine)","count":14,"properties2":{"reactions":7,"completeness":0.714285714285714,"reactions_with_gene":5,"genes":14,"norm_chokepoint":1.0,"druggable":"Yes","max_centrality":0.02873,"norm_reactions":0.12280701754386,"chokepoints":7},"properties":null,"score":0.0},{"term":"THIOREDOX-PWY","name":"thioredoxin pathway","count":1,"properties2":{"reactions":2,"completeness":0.5,"reactions_with_gene":1,"genes":1,"norm_chokepoint":0.0,"druggable":"No","max_centrality":0.0185,"norm_reactions":0.0350877192982456,"chokepoints":0},"properties":null,"score":0.0},{"term":"PWY0-1301","name":"melibiose degradation","count":8,"properties2":{"reactions":4,"completeness":1.0,"reactions_with_gene":4,"genes":8,"norm_chokepoint":0.0,"druggable":"No","max_centrality":0.0,"norm_reactions":0.0701754385964912,"chokepoints":0},"properties":null,"score":0.0},{"term":"PWY-5669","name":"phosphatidylethanolamine biosynthesis I","count":2,"properties2":{"reactions":2,"completeness":1.0,"reactions_with_gene":2,"genes":2,"norm_chokepoint":1.0,"druggable":"Yes","max_centrality":0.233635006239553,"norm_reactions":0.0350877192982456,"chokepoints":2},"properties":null,"score":0.0},{"term":"PWY-5667","name":"CDP-diacylglycerol biosynthesis I","count":8,"properties2":{"reactions":5,"completeness":1.0,"reactions_with_gene":5,"genes":8,"norm_chokepoint":0.2,"druggable":"No","max_centrality":0.139305043533121,"norm_reactions":0.087719298245614,"chokepoints":1},"properties":null,"score":0.0},{"term":"PWY0-1309","name":"chitobiose degradation","count":12,"properties2":{"reactions":2,"completeness":1.0,"reactions_with_gene":2,"genes":12,"norm_chokepoint":1.0,"druggable":"Yes","max_centrality":1.0E-5,"norm_reactions":0.0350877192982456,"chokepoints":2},"properties":null,"score":0.0},{"term":"PWY-5148","name":"acyl-CoA hydrolysis","count":15,"properties2":{"reactions":5,"completeness":1.0,"reactions_with_gene":5,"genes":15,"norm_chokepoint":0.0,"druggable":"No","max_centrality":0.0714243647693342,"norm_reactions":0.087719298245614,"chokepoints":0},"properties":null,"score":0.0},{"term":"COA-PWY","name":"coenzyme A biosynthesis","count":4,"properties2":{"reactions":4,"completeness":1.0,"reactions_with_gene":4,"genes":4,"norm_chokepoint":0.75,"druggable":"Yes","max_centrality":0.126444331147014,"norm_reactions":0.0701754385964912,"chokepoints":3},"properties":null,"score":0.0},{"term":"XYLCAT-PWY","name":"xylose degradation I","count":4,"properties2":{"reactions":3,"completeness":1.0,"reactions_with_gene":3,"genes":4,"norm_chokepoint":1.0,"druggable":"Yes","max_centrality":0.0233631099712776,"norm_reactions":0.0526315789473684,"chokepoints":3},"properties":null,"score":0.0},{"term":"PWY-5989","name":"stearate biosynthesis II (bacteria and plants)","count":9,"properties2":{"reactions":6,"completeness":0.833333333333333,"reactions_with_gene":5,"genes":9,"norm_chokepoint":0.5,"druggable":"Yes","max_centrality":0.64152,"norm_reactions":0.105263157894737,"chokepoints":3},"properties":null,"score":0.0},{"term":"PWY-5838","name":"superpathway of menaquinol-8 biosynthesis I","count":13,"properties2":{"reactions":10,"completeness":1.0,"reactions_with_gene":10,"genes":13,"norm_chokepoint":0.8,"druggable":"Yes","max_centrality":0.116477620429252,"norm_reactions":0.175438596491228,"chokepoints":8},"properties":null,"score":0.0},{"term":"PROTOCATECHUATE-ORTHO-CLEAVAGE-PWY","name":"protocatechuate degradation II (ortho-cleavage pathway)","count":7,"properties2":{"reactions":4,"completeness":0.5,"reactions_with_gene":2,"genes":7,"norm_chokepoint":1.0,"druggable":"Yes","max_centrality":0.132525029515047,"norm_reactions":0.0701754385964912,"chokepoints":4},"properties":null,"score":0.0},{"term":"ASPARTATESYN-PWY","name":"aspartate biosynthesis","count":1,"properties2":{"reactions":1,"completeness":1.0,"reactions_with_gene":1,"genes":1,"norm_chokepoint":0.0,"druggable":"Yes","max_centrality":0.03642,"norm_reactions":0.0175438596491228,"chokepoints":0},"properties":null,"score":0.0},{"term":"FERMENTATION-PWY","name":"mixed acid fermentation","count":42,"properties2":{"reactions":18,"completeness":1.0,"reactions_with_gene":18,"genes":42,"norm_chokepoint":0.444444444444444,"druggable":"Yes","max_centrality":1.0,"norm_reactions":0.315789473684211,"chokepoints":8},"properties":null,"score":0.0},{"term":"PWY0-1275","name":"lipoate biosynthesis and incorporation II","count":3,"properties2":{"reactions":2,"completeness":1.0,"reactions_with_gene":2,"genes":3,"norm_chokepoint":0.5,"druggable":"Yes","max_centrality":0.202564084485117,"norm_reactions":0.0350877192982456,"chokepoints":1},"properties":null,"score":0.0},{"term":"PWY-7199","name":"pyrimidine deoxyribonucleosides salvage","count":4,"properties2":{"reactions":13,"completeness":0.307692307692308,"reactions_with_gene":4,"genes":4,"norm_chokepoint":0.153846153846154,"druggable":"Yes","max_centrality":0.14956,"norm_reactions":0.228070175438596,"chokepoints":2},"properties":null,"score":0.0},{"term":"PARATHION-DEGRADATION-PWY","name":"parathion degradation","count":1,"properties2":{"reactions":2,"completeness":0.5,"reactions_with_gene":1,"genes":1,"norm_chokepoint":1.0,"druggable":"Yes","max_centrality":0.00934524398851102,"norm_reactions":0.0350877192982456,"chokepoints":2},"properties":null,"score":0.0},{"term":"PWY-6502","name":"oxidized GTP and dGTP detoxification","count":2,"properties2":{"reactions":4,"completeness":0.5,"reactions_with_gene":2,"genes":2,"norm_chokepoint":1.0,"druggable":"Yes","max_centrality":0.00519088086673283,"norm_reactions":0.0701754385964912,"chokepoints":4},"properties":null,"score":0.0},{"term":"PWY-7193","name":"pyrimidine ribonucleosides salvage I","count":3,"properties2":{"reactions":3,"completeness":1.0,"reactions_with_gene":3,"genes":3,"norm_chokepoint":0.0,"druggable":"Yes","max_centrality":0.02236,"norm_reactions":0.0526315789473684,"chokepoints":0},"properties":null,"score":0.0},{"term":"PWY-7197","name":"pyrimidine deoxyribonucleotide phosphorylation","count":4,"properties2":{"reactions":4,"completeness":1.0,"reactions_with_gene":4,"genes":4,"norm_chokepoint":1.0,"druggable":"Yes","max_centrality":0.04695,"norm_reactions":0.0701754385964912,"chokepoints":4},"properties":null,"score":0.0},{"term":"NAD-BIOSYNTHESIS-II","name":"NAD salvage pathway II","count":9,"properties2":{"reactions":5,"completeness":1.0,"reactions_with_gene":5,"genes":9,"norm_chokepoint":0.4,"druggable":"Yes","max_centrality":1.0E-5,"norm_reactions":0.087719298245614,"chokepoints":2},"properties":null,"score":0.0},{"term":"PWY-7394","name":"urate degradation to allantoin II","count":4,"properties2":{"reactions":3,"completeness":1.0,"reactions_with_gene":3,"genes":4,"norm_chokepoint":0.666666666666667,"druggable":"Yes","max_centrality":0.0072,"norm_reactions":0.0526315789473684,"chokepoints":2},"properties":null,"score":0.0},{"term":"PWY-6517","name":"N-acetylglucosamine degradation II","count":4,"properties2":{"reactions":3,"completeness":1.0,"reactions_with_gene":3,"genes":4,"norm_chokepoint":0.666666666666667,"druggable":"Yes","max_centrality":0.06008,"norm_reactions":0.0526315789473684,"chokepoints":2},"properties":null,"score":0.0},{"term":"GLYCLEAV-PWY","name":"glycine cleavage","count":6,"properties2":{"reactions":3,"completeness":1.0,"reactions_with_gene":3,"genes":6,"norm_chokepoint":1.0,"druggable":"Yes","max_centrality":0.215707347226382,"norm_reactions":0.0526315789473684,"chokepoints":3},"properties":null,"score":0.0},{"term":"DENOVOPURINE2-PWY","name":"purine nucleotides de novo biosynthesis I","count":41,"properties2":{"reactions":29,"completeness":0.96551724137931,"reactions_with_gene":28,"genes":41,"norm_chokepoint":0.482758620689655,"druggable":"Yes","max_centrality":0.34351,"norm_reactions":0.508771929824561,"chokepoints":14},"properties":null,"score":0.0},{"term":"PWY-6147","name":"6-hydroxymethyl-dihydropterin diphosphate biosynthesis I","count":5,"properties2":{"reactions":5,"completeness":1.0,"reactions_with_gene":5,"genes":5,"norm_chokepoint":1.0,"druggable":"Yes","max_centrality":0.181017206308722,"norm_reactions":0.087719298245614,"chokepoints":5},"properties":null,"score":0.0},{"term":"CATECHOL-ORTHO-CLEAVAGE-PWY","name":"catechol degradation to β-ketoadipate","count":4,"properties2":{"reactions":4,"completeness":0.75,"reactions_with_gene":3,"genes":4,"norm_chokepoint":1.0,"druggable":"Yes","max_centrality":0.132525029515047,"norm_reactions":0.0701754385964912,"chokepoints":4},"properties":null,"score":0.0},{"term":"PYRUVDEHYD-PWY","name":"acetyl-CoA biosynthesis (from pyruvate)","count":7,"properties2":{"reactions":5,"completeness":1.0,"reactions_with_gene":5,"genes":7,"norm_chokepoint":0.8,"druggable":"Yes","max_centrality":0.06639,"norm_reactions":0.087719298245614,"chokepoints":4},"properties":null,"score":0.0},{"term":"DARABITOLUTIL-PWY","name":"D-arabitol degradation","count":3,"properties2":{"reactions":2,"completeness":1.0,"reactions_with_gene":2,"genes":3,"norm_chokepoint":1.0,"druggable":"Yes","max_centrality":0.0233631099712776,"norm_reactions":0.0350877192982456,"chokepoints":2},"properties":null,"score":0.0},{"term":"PWY0-541","name":"cyclopropane fatty acid (CFA) biosynthesis","count":2,"properties2":{"reactions":1,"completeness":1.0,"reactions_with_gene":1,"genes":2,"norm_chokepoint":1.0,"druggable":"No","max_centrality":0.0,"norm_reactions":0.0175438596491228,"chokepoints":1},"properties":null,"score":0.0},{"term":"PWY0-461","name":"lysine degradation I","count":2,"properties2":{"reactions":1,"completeness":1.0,"reactions_with_gene":1,"genes":2,"norm_chokepoint":1.0,"druggable":"Yes","max_centrality":0.00719,"norm_reactions":0.0175438596491228,"chokepoints":1},"properties":null,"score":0.0},{"term":"PWY-7343","name":"UDP-glucose biosynthesis","count":7,"properties2":{"reactions":6,"completeness":1.0,"reactions_with_gene":6,"genes":7,"norm_chokepoint":0.333333333333333,"druggable":"Yes","max_centrality":0.24542304776584,"norm_reactions":0.105263157894737,"chokepoints":2},"properties":null,"score":0.0},{"term":"PWY-6754","name":"S-methyl-5'-thioadenosine degradation I","count":2,"properties2":{"reactions":2,"completeness":1.0,"reactions_with_gene":2,"genes":2,"norm_chokepoint":1.0,"druggable":"Yes","max_centrality":0.0847172816915065,"norm_reactions":0.0350877192982456,"chokepoints":2},"properties":null,"score":0.0},{"term":"PWY-4081","name":"glutathione redox reactions I","count":2,"properties2":{"reactions":3,"completeness":0.666666666666667,"reactions_with_gene":2,"genes":2,"norm_chokepoint":0.333333333333333,"druggable":"Yes","max_centrality":0.0,"norm_reactions":0.0526315789473684,"chokepoints":1},"properties":null,"score":0.0},{"term":"P4-PWY","name":"superpathway of lysine, threonine and methionine biosynthesis I","count":29,"properties2":{"reactions":18,"completeness":1.0,"reactions_with_gene":18,"genes":29,"norm_chokepoint":0.722222222222222,"druggable":"Yes","max_centrality":0.518882338645114,"norm_reactions":0.315789473684211,"chokepoints":13},"properties":null,"score":0.0},{"term":"PWY-6618","name":"guanine and guanosine salvage III","count":1,"properties2":{"reactions":1,"completeness":1.0,"reactions_with_gene":1,"genes":1,"norm_chokepoint":0.0,"druggable":"Yes","max_centrality":0.0139398732755473,"norm_reactions":0.0175438596491228,"chokepoints":0},"properties":null,"score":0.0},{"term":"SALVPURINE2-PWY","name":"xanthine and xanthosine salvage","count":2,"properties2":{"reactions":2,"completeness":1.0,"reactions_with_gene":2,"genes":2,"norm_chokepoint":0.5,"druggable":"Yes","max_centrality":0.02597,"norm_reactions":0.0350877192982456,"chokepoints":1},"properties":null,"score":0.0},{"term":"ENTBACSYN-PWY","name":"enterobactin biosynthesis","count":25,"properties2":{"reactions":11,"completeness":1.0,"reactions_with_gene":11,"genes":25,"norm_chokepoint":1.0,"druggable":"Yes","max_centrality":0.0772045608707471,"norm_reactions":0.192982456140351,"chokepoints":11},"properties":null,"score":0.0},{"term":"PWY-6614","name":"tetrahydrofolate biosynthesis","count":8,"properties2":{"reactions":3,"completeness":1.0,"reactions_with_gene":3,"genes":8,"norm_chokepoint":1.0,"druggable":"Yes","max_centrality":0.11203,"norm_reactions":0.0526315789473684,"chokepoints":3},"properties":null,"score":0.0},{"term":"PWY-6612","name":"superpathway of tetrahydrofolate biosynthesis","count":16,"properties2":{"reactions":10,"completeness":1.0,"reactions_with_gene":10,"genes":16,"norm_chokepoint":1.0,"druggable":"Yes","max_centrality":0.181017206308722,"norm_reactions":0.175438596491228,"chokepoints":10},"properties":null,"score":0.0},{"term":"PWY-4361","name":"methionine salvage I","count":5,"properties2":{"reactions":6,"completeness":0.833333333333333,"reactions_with_gene":5,"genes":5,"norm_chokepoint":0.5,"druggable":"Yes","max_centrality":0.88264,"norm_reactions":0.105263157894737,"chokepoints":3},"properties":null,"score":0.0},{"term":"PWY-6611","name":"adenine and adenosine salvage V","count":3,"properties2":{"reactions":3,"completeness":1.0,"reactions_with_gene":3,"genes":3,"norm_chokepoint":0.0,"druggable":"Yes","max_centrality":0.0950943002123338,"norm_reactions":0.0526315789473684,"chokepoints":0},"properties":null,"score":0.0},{"term":"PWY-5431","name":"aromatic compounds degradation via β-ketoadipate","count":13,"properties2":{"reactions":9,"completeness":0.777777777777778,"reactions_with_gene":7,"genes":13,"norm_chokepoint":0.888888888888889,"druggable":"Yes","max_centrality":0.157138838258809,"norm_reactions":0.157894736842105,"chokepoints":8},"properties":null,"score":0.0},{"term":"LPSSYN-PWY","name":"superpathway of lipopolysaccharide biosynthesis","count":20,"properties2":{"reactions":25,"completeness":0.72,"reactions_with_gene":18,"genes":20,"norm_chokepoint":1.0,"druggable":"Yes","max_centrality":0.28751,"norm_reactions":0.43859649122807,"chokepoints":25},"properties":null,"score":0.0},{"term":"PWY-2201","name":"folate transformations I","count":16,"properties2":{"reactions":14,"completeness":0.928571428571429,"reactions_with_gene":13,"genes":16,"norm_chokepoint":0.428571428571429,"druggable":"Yes","max_centrality":0.632073787311858,"norm_reactions":0.245614035087719,"chokepoints":6},"properties":null,"score":0.0},{"term":"GLYOXYLATE-BYPASS","name":"glyoxylate cycle","count":9,"properties2":{"reactions":6,"completeness":1.0,"reactions_with_gene":6,"genes":9,"norm_chokepoint":0.666666666666667,"druggable":"Yes","max_centrality":0.27487,"norm_reactions":0.105263157894737,"chokepoints":4},"properties":null,"score":0.0},{"term":"PWY-5041","name":"S-adenosyl-L-methionine cycle II","count":5,"properties2":{"reactions":4,"completeness":0.75,"reactions_with_gene":3,"genes":5,"norm_chokepoint":0.5,"druggable":"Yes","max_centrality":0.56331,"norm_reactions":0.0701754385964912,"chokepoints":2},"properties":null,"score":0.0},{"term":"PWY-5340","name":"sulfate activation for sulfonation","count":3,"properties2":{"reactions":2,"completeness":1.0,"reactions_with_gene":2,"genes":3,"norm_chokepoint":1.0,"druggable":"Yes","max_centrality":0.01354,"norm_reactions":0.0350877192982456,"chokepoints":2},"properties":null,"score":0.0},{"term":"PANTO-PWY","name":"phosphopantothenate biosynthesis I","count":5,"properties2":{"reactions":4,"completeness":1.0,"reactions_with_gene":4,"genes":5,"norm_chokepoint":0.75,"druggable":"Yes","max_centrality":0.106943441116842,"norm_reactions":0.0701754385964912,"chokepoints":3},"properties":null,"score":0.0},{"term":"PWY0-823","name":"arginine degradation III (arginine decarboxylase/agmatinase pathway)","count":2,"properties2":{"reactions":2,"completeness":1.0,"reactions_with_gene":2,"genes":2,"norm_chokepoint":1.0,"druggable":"Yes","max_centrality":0.00784,"norm_reactions":0.0350877192982456,"chokepoints":2},"properties":null,"score":0.0},{"term":"PWY0-381","name":"glycerol degradation I","count":6,"properties2":{"reactions":2,"completeness":1.0,"reactions_with_gene":2,"genes":6,"norm_chokepoint":0.0,"druggable":"Yes","max_centrality":1.50295073018423E-4,"norm_reactions":0.0350877192982456,"chokepoints":0},"properties":null,"score":0.0},{"term":"PWY-6932","name":"selenate reduction","count":2,"properties2":{"reactions":5,"completeness":0.2,"reactions_with_gene":1,"genes":2,"norm_chokepoint":1.0,"druggable":"Yes","max_centrality":0.00471872235491206,"norm_reactions":0.087719298245614,"chokepoints":5},"properties":null,"score":0.0},{"term":"PWY-5629","name":"isopenicillin N biosynthesis","count":1,"properties2":{"reactions":2,"completeness":0.5,"reactions_with_gene":1,"genes":1,"norm_chokepoint":1.0,"druggable":"No","max_centrality":0.00518673479575301,"norm_reactions":0.0350877192982456,"chokepoints":2},"properties":null,"score":0.0},{"term":"PWY-5188","name":"tetrapyrrole biosynthesis I","count":6,"properties2":{"reactions":6,"completeness":1.0,"reactions_with_gene":6,"genes":6,"norm_chokepoint":1.0,"druggable":"Yes","max_centrality":0.0644,"norm_reactions":0.105263157894737,"chokepoints":6},"properties":null,"score":0.0},{"term":"PWY-3001","name":"isoleucine biosynthesis I","count":26,"properties2":{"reactions":14,"completeness":0.857142857142857,"reactions_with_gene":12,"genes":26,"norm_chokepoint":0.785714285714286,"druggable":"Yes","max_centrality":0.05219,"norm_reactions":0.245614035087719,"chokepoints":11},"properties":null,"score":0.0},{"term":"PWY-6519","name":"8-amino-7-oxononanoate biosynthesis I","count":16,"properties2":{"reactions":11,"completeness":1.0,"reactions_with_gene":11,"genes":16,"norm_chokepoint":1.0,"druggable":"Yes","max_centrality":0.12397,"norm_reactions":0.192982456140351,"chokepoints":11},"properties":null,"score":0.0},{"term":"PWY-2301","name":"myo-inositol biosynthesis","count":3,"properties2":{"reactions":3,"completeness":0.333333333333333,"reactions_with_gene":1,"genes":3,"norm_chokepoint":0.333333333333333,"druggable":"Yes","max_centrality":0.07748,"norm_reactions":0.0526315789473684,"chokepoints":1},"properties":null,"score":0.0},{"term":"FASYN-ELONG-PWY","name":"fatty acid elongation -- saturated","count":7,"properties2":{"reactions":13,"completeness":0.307692307692308,"reactions_with_gene":4,"genes":7,"norm_chokepoint":0.153846153846154,"druggable":"No","max_centrality":0.00937012041438993,"norm_reactions":0.228070175438596,"chokepoints":2},"properties":null,"score":0.0},{"term":"PWY-6277","name":"superpathway of 5-aminoimidazole ribonucleotide biosynthesis","count":7,"properties2":{"reactions":6,"completeness":1.0,"reactions_with_gene":6,"genes":7,"norm_chokepoint":0.666666666666667,"druggable":"Yes","max_centrality":0.12427,"norm_reactions":0.105263157894737,"chokepoints":4},"properties":null,"score":0.0},{"term":"PWY-7237","name":"myo-, chiro- and scillo-inositol degradation","count":8,"properties2":{"reactions":10,"completeness":0.7,"reactions_with_gene":7,"genes":8,"norm_chokepoint":0.8,"druggable":"Yes","max_centrality":0.11091,"norm_reactions":0.175438596491228,"chokepoints":8},"properties":null,"score":0.0},{"term":"AMMASSIM-PWY","name":"ammonia assimilation cycle III","count":16,"properties2":{"reactions":4,"completeness":1.0,"reactions_with_gene":4,"genes":16,"norm_chokepoint":0.0,"druggable":"Yes","max_centrality":0.18303,"norm_reactions":0.0701754385964912,"chokepoints":0},"properties":null,"score":0.0},{"term":"THREONINE-DEG2-PWY","name":"threonine degradation II","count":2,"properties2":{"reactions":2,"completeness":1.0,"reactions_with_gene":2,"genes":2,"norm_chokepoint":0.0,"druggable":"Yes","max_centrality":0.02098,"norm_reactions":0.0350877192982456,"chokepoints":0},"properties":null,"score":0.0},{"term":"PWY-5695","name":"urate biosynthesis/inosine 5'-phosphate degradation","count":7,"properties2":{"reactions":4,"completeness":1.0,"reactions_with_gene":4,"genes":7,"norm_chokepoint":0.75,"druggable":"Yes","max_centrality":0.05573,"norm_reactions":0.0701754385964912,"chokepoints":3},"properties":null,"score":0.0},{"term":"PWY3O-4106","name":"NAD salvage pathway III","count":2,"properties2":{"reactions":2,"completeness":1.0,"reactions_with_gene":2,"genes":2,"norm_chokepoint":0.5,"druggable":"Yes","max_centrality":1.0E-5,"norm_reactions":0.0350877192982456,"chokepoints":1},"properties":null,"score":0.0},{"term":"PWY-5691","name":"urate degradation to allantoin","count":4,"properties2":{"reactions":3,"completeness":1.0,"reactions_with_gene":3,"genes":4,"norm_chokepoint":0.666666666666667,"druggable":"Yes","max_centrality":0.0072,"norm_reactions":0.0526315789473684,"chokepoints":2},"properties":null,"score":0.0},{"term":"HOMOSERSYN-PWY","name":"homoserine biosynthesis","count":9,"properties2":{"reactions":4,"completeness":1.0,"reactions_with_gene":4,"genes":9,"norm_chokepoint":0.5,"druggable":"Yes","max_centrality":0.05219,"norm_reactions":0.0701754385964912,"chokepoints":2},"properties":null,"score":0.0},{"term":"PLPSAL-PWY","name":"pyridoxal 5'-phosphate salvage pathway","count":8,"properties2":{"reactions":5,"completeness":1.0,"reactions_with_gene":5,"genes":8,"norm_chokepoint":0.8,"druggable":"Yes","max_centrality":0.01446,"norm_reactions":0.087719298245614,"chokepoints":4},"properties":null,"score":0.0},{"term":"GALACTCAT-PWY","name":"D-galactonate degradation","count":5,"properties2":{"reactions":3,"completeness":1.0,"reactions_with_gene":3,"genes":5,"norm_chokepoint":1.0,"druggable":"Yes","max_centrality":0.01354,"norm_reactions":0.0526315789473684,"chokepoints":3},"properties":null,"score":0.0},{"term":"PWY0-1338","name":"polymyxin resistance","count":6,"properties2":{"reactions":6,"completeness":1.0,"reactions_with_gene":6,"genes":6,"norm_chokepoint":1.0,"druggable":"Yes","max_centrality":0.0967337205410154,"norm_reactions":0.105263157894737,"chokepoints":6},"properties":null,"score":0.0},{"term":"SULFATE-CYS-PWY","name":"superpathway of sulfate assimilation and cysteine biosynthesis","count":12,"properties2":{"reactions":9,"completeness":1.0,"reactions_with_gene":9,"genes":12,"norm_chokepoint":0.777777777777778,"druggable":"Yes","max_centrality":0.30432,"norm_reactions":0.157894736842105,"chokepoints":7},"properties":null,"score":0.0},{"term":"PWY-5137","name":"fatty acid β-oxidation III (unsaturated, odd number)","count":8,"properties2":{"reactions":8,"completeness":1.0,"reactions_with_gene":8,"genes":8,"norm_chokepoint":1.0,"druggable":"No","max_centrality":0.0,"norm_reactions":0.140350877192982,"chokepoints":8},"properties":null,"score":0.0},{"term":"PWY-7013","name":"L-1,2-propanediol degradation","count":14,"properties2":{"reactions":5,"completeness":1.0,"reactions_with_gene":5,"genes":14,"norm_chokepoint":0.8,"druggable":"Yes","max_centrality":0.0721062843383834,"norm_reactions":0.087719298245614,"chokepoints":4},"properties":null,"score":0.0},{"term":"HISTSYN-PWY","name":"histidine biosynthesis","count":13,"properties2":{"reactions":10,"completeness":1.0,"reactions_with_gene":10,"genes":13,"norm_chokepoint":1.0,"druggable":"Yes","max_centrality":0.24991,"norm_reactions":0.175438596491228,"chokepoints":10},"properties":null,"score":0.0},{"term":"PWY-6387","name":"UDP-N-acetylmuramoyl-pentapeptide biosynthesis I (meso-DAP-containing)","count":8,"properties2":{"reactions":8,"completeness":1.0,"reactions_with_gene":8,"genes":8,"norm_chokepoint":1.0,"druggable":"Yes","max_centrality":0.07715,"norm_reactions":0.140350877192982,"chokepoints":8},"properties":null,"score":0.0},{"term":"PWY-6389","name":"(S)-acetoin biosynthesis","count":9,"properties2":{"reactions":3,"completeness":0.666666666666667,"reactions_with_gene":2,"genes":9,"norm_chokepoint":1.0,"druggable":"Yes","max_centrality":0.03587,"norm_reactions":0.0526315789473684,"chokepoints":3},"properties":null,"score":0.0},{"term":"ASPARTATE-DEG1-PWY","name":"aspartate degradation I","count":1,"properties2":{"reactions":1,"completeness":1.0,"reactions_with_gene":1,"genes":1,"norm_chokepoint":0.0,"druggable":"Yes","max_centrality":0.03642,"norm_reactions":0.0175438596491228,"chokepoints":0},"properties":null,"score":0.0},{"term":"PWY0-1241","name":"ADP-L-glycero-β-D-manno-heptose biosynthesis","count":5,"properties2":{"reactions":5,"completeness":1.0,"reactions_with_gene":5,"genes":5,"norm_chokepoint":1.0,"druggable":"Yes","max_centrality":0.02894,"norm_reactions":0.087719298245614,"chokepoints":5},"properties":null,"score":0.0},{"term":"PWY-6499","name":"D-glucarate degradation II","count":2,"properties2":{"reactions":3,"completeness":0.333333333333333,"reactions_with_gene":1,"genes":2,"norm_chokepoint":1.0,"druggable":"Yes","max_centrality":0.00679,"norm_reactions":0.0526315789473684,"chokepoints":3},"properties":null,"score":0.0},{"term":"PWY-5155","name":"β-alanine biosynthesis III","count":1,"properties2":{"reactions":1,"completeness":1.0,"reactions_with_gene":1,"genes":1,"norm_chokepoint":1.0,"druggable":"Yes","max_centrality":0.04174,"norm_reactions":0.0175438596491228,"chokepoints":1},"properties":null,"score":0.0},{"term":"P641-PWY","name":"phenylmercury acetate degradation","count":1,"properties2":{"reactions":2,"completeness":0.5,"reactions_with_gene":1,"genes":1,"norm_chokepoint":1.0,"druggable":"Yes","max_centrality":0.0,"norm_reactions":0.0350877192982456,"chokepoints":2},"properties":null,"score":0.0},{"term":"PWY-6497","name":"D-galactarate degradation II","count":1,"properties2":{"reactions":3,"completeness":0.333333333333333,"reactions_with_gene":1,"genes":1,"norm_chokepoint":1.0,"druggable":"No","max_centrality":1.24382129394557E-5,"norm_reactions":0.0526315789473684,"chokepoints":3},"properties":null,"score":0.0},{"term":"DARABCAT-PWY","name":"D-arabinose degradation II","count":2,"properties2":{"reactions":2,"completeness":1.0,"reactions_with_gene":2,"genes":2,"norm_chokepoint":1.0,"druggable":"Yes","max_centrality":0.05415,"norm_reactions":0.0350877192982456,"chokepoints":2},"properties":null,"score":0.0},{"term":"PWY-40","name":"putrescine biosynthesis I","count":2,"properties2":{"reactions":2,"completeness":1.0,"reactions_with_gene":2,"genes":2,"norm_chokepoint":1.0,"druggable":"Yes","max_centrality":0.00784,"norm_reactions":0.0350877192982456,"chokepoints":2},"properties":null,"score":0.0},{"term":"PWY-46","name":"putrescine biosynthesis III","count":1,"properties2":{"reactions":1,"completeness":1.0,"reactions_with_gene":1,"genes":1,"norm_chokepoint":0.0,"druggable":"Yes","max_centrality":0.142336268263367,"norm_reactions":0.0175438596491228,"chokepoints":0},"properties":null,"score":0.0},{"term":"TRNA-CHARGING-PWY","name":"tRNA charging pathway","count":24,"properties2":{"reactions":21,"completeness":0.904761904761905,"reactions_with_gene":19,"genes":24,"norm_chokepoint":0.952380952380952,"druggable":"Yes","max_centrality":0.0644,"norm_reactions":0.368421052631579,"chokepoints":20},"properties":null,"score":0.0},{"term":"PWY0-1415","name":"superpathway of heme biosynthesis from uroporphyrinogen-III","count":6,"properties2":{"reactions":6,"completeness":1.0,"reactions_with_gene":6,"genes":6,"norm_chokepoint":0.666666666666667,"druggable":"Yes","max_centrality":0.07419,"norm_reactions":0.105263157894737,"chokepoints":4},"properties":null,"score":0.0},{"term":"PWY-4984","name":"urea cycle","count":12,"properties2":{"reactions":8,"completeness":1.0,"reactions_with_gene":8,"genes":12,"norm_chokepoint":0.5,"druggable":"Yes","max_centrality":0.0737750560884987,"norm_reactions":0.140350877192982,"chokepoints":4},"properties":null,"score":0.0},{"term":"GLUCONSUPER-PWY","name":"D-gluconate degradation","count":1,"properties2":{"reactions":1,"completeness":1.0,"reactions_with_gene":1,"genes":1,"norm_chokepoint":0.0,"druggable":"Yes","max_centrality":0.04186,"norm_reactions":0.0175438596491228,"chokepoints":0},"properties":null,"score":0.0},{"term":"PWY-5704","name":"urea degradation II","count":3,"properties2":{"reactions":1,"completeness":1.0,"reactions_with_gene":1,"genes":3,"norm_chokepoint":1.0,"druggable":"Yes","max_centrality":0.0,"norm_reactions":0.0175438596491228,"chokepoints":1},"properties":null,"score":0.0},{"term":"ANAEROFRUCAT-PWY","name":"homolactic fermentation","count":32,"properties2":{"reactions":17,"completeness":1.0,"reactions_with_gene":17,"genes":32,"norm_chokepoint":0.117647058823529,"druggable":"Yes","max_centrality":0.319,"norm_reactions":0.298245614035088,"chokepoints":2},"properties":null,"score":0.0},{"term":"BIOTIN-BIOSYNTHESIS-PWY","name":"biotin biosynthesis I","count":20,"properties2":{"reactions":14,"completeness":1.0,"reactions_with_gene":14,"genes":20,"norm_chokepoint":1.0,"druggable":"Yes","max_centrality":0.22137,"norm_reactions":0.245614035087719,"chokepoints":14},"properties":null,"score":0.0},{"term":"PWY66-422","name":"D-galactose degradation V (Leloir pathway)","count":10,"properties2":{"reactions":9,"completeness":1.0,"reactions_with_gene":9,"genes":10,"norm_chokepoint":0.444444444444444,"druggable":"Yes","max_centrality":0.188902548552899,"norm_reactions":0.157894736842105,"chokepoints":4},"properties":null,"score":0.0},{"term":"PWY-5901","name":"2,3-dihydroxybenzoate biosynthesis","count":9,"properties2":{"reactions":3,"completeness":1.0,"reactions_with_gene":3,"genes":9,"norm_chokepoint":1.0,"druggable":"Yes","max_centrality":0.0772045608707471,"norm_reactions":0.0526315789473684,"chokepoints":3},"properties":null,"score":0.0},{"term":"PWY-7377","name":"cob(II)yrinate a,c-diamide biosynthesis I (early cobalt insertion)","count":18,"properties2":{"reactions":17,"completeness":0.647058823529412,"reactions_with_gene":11,"genes":18,"norm_chokepoint":0.941176470588235,"druggable":"Yes","max_centrality":0.32207,"norm_reactions":0.298245614035088,"chokepoints":16},"properties":null,"score":0.0},{"term":"FOLSYN-PWY","name":"tetrahydrofolate biosynthesis","count":18,"properties2":{"reactions":12,"completeness":1.0,"reactions_with_gene":12,"genes":18,"norm_chokepoint":0.916666666666667,"druggable":"Yes","max_centrality":0.181017206308722,"norm_reactions":0.210526315789474,"chokepoints":11},"properties":null,"score":0.0},{"term":"PWY-1269","name":"CMP-KDO biosynthesis I","count":5,"properties2":{"reactions":5,"completeness":0.8,"reactions_with_gene":4,"genes":5,"norm_chokepoint":1.0,"druggable":"Yes","max_centrality":0.06726,"norm_reactions":0.087719298245614,"chokepoints":5},"properties":null,"score":0.0},{"term":"PWY-7528","name":"L-methionine salvage cycle I (bacteria and plants)","count":10,"properties2":{"reactions":11,"completeness":0.909090909090909,"reactions_with_gene":10,"genes":10,"norm_chokepoint":0.727272727272727,"druggable":"Yes","max_centrality":0.88264,"norm_reactions":0.192982456140351,"chokepoints":8},"properties":null,"score":0.0},{"term":"PWY-5796","name":"2'-(5'-phosphoribosyl)-3'-dephospho-CoA biosynthesis II (malonate decarboxylase)","count":2,"properties2":{"reactions":2,"completeness":1.0,"reactions_with_gene":2,"genes":2,"norm_chokepoint":1.0,"druggable":"No","max_centrality":0.0667845230174446,"norm_reactions":0.0350877192982456,"chokepoints":2},"properties":null,"score":0.0},{"term":"PWY-5417","name":"catechol degradation III (ortho-cleavage pathway)","count":6,"properties2":{"reactions":6,"completeness":0.833333333333333,"reactions_with_gene":5,"genes":6,"norm_chokepoint":0.833333333333333,"druggable":"Yes","max_centrality":0.157138838258809,"norm_reactions":0.105263157894737,"chokepoints":5},"properties":null,"score":0.0},{"term":"PWY0-1466","name":"trehalose degradation VI (periplasmic)","count":3,"properties2":{"reactions":2,"completeness":1.0,"reactions_with_gene":2,"genes":3,"norm_chokepoint":0.5,"druggable":"Yes","max_centrality":0.00676,"norm_reactions":0.0350877192982456,"chokepoints":1},"properties":null,"score":0.0},{"term":"GLUTAMINEFUM-PWY","name":"glutamine degradation II","count":15,"properties2":{"reactions":3,"completeness":1.0,"reactions_with_gene":3,"genes":15,"norm_chokepoint":0.0,"druggable":"Yes","max_centrality":0.00234,"norm_reactions":0.0526315789473684,"chokepoints":0},"properties":null,"score":0.0},{"term":"GLYCOLYSIS","name":"glycolysis I","count":33,"properties2":{"reactions":15,"completeness":1.0,"reactions_with_gene":15,"genes":33,"norm_chokepoint":0.133333333333333,"druggable":"Yes","max_centrality":0.319,"norm_reactions":0.263157894736842,"chokepoints":2},"properties":null,"score":0.0},{"term":"TRESYN-PWY","name":"trehalose biosynthesis I","count":3,"properties2":{"reactions":3,"completeness":1.0,"reactions_with_gene":3,"genes":3,"norm_chokepoint":0.333333333333333,"druggable":"Yes","max_centrality":0.115834924059614,"norm_reactions":0.0526315789473684,"chokepoints":1},"properties":null,"score":0.0},{"term":"MENAQUINONESYN-PWY","name":"menaquinone-8 biosynthesis","count":1,"properties2":{"reactions":1,"completeness":1.0,"reactions_with_gene":1,"genes":1,"norm_chokepoint":1.0,"druggable":"Yes","max_centrality":0.0,"norm_reactions":0.0175438596491228,"chokepoints":1},"properties":null,"score":0.0},{"term":"GLYCOGENSYNTH-PWY","name":"glycogen biosynthesis I (from ADP-D-Glucose)","count":6,"properties2":{"reactions":6,"completeness":1.0,"reactions_with_gene":6,"genes":6,"norm_chokepoint":0.333333333333333,"druggable":"Yes","max_centrality":0.11027,"norm_reactions":0.105263157894737,"chokepoints":2},"properties":null,"score":0.0},{"term":"PWY-6044","name":"methanesulfonate degradation","count":1,"properties2":{"reactions":1,"completeness":1.0,"reactions_with_gene":1,"genes":1,"norm_chokepoint":0.0,"druggable":"Yes","max_centrality":0.0,"norm_reactions":0.0175438596491228,"chokepoints":0},"properties":null,"score":0.0},{"term":"PWY-5386","name":"methylglyoxal degradation I","count":4,"properties2":{"reactions":3,"completeness":1.0,"reactions_with_gene":3,"genes":4,"norm_chokepoint":1.0,"druggable":"Yes","max_centrality":0.00717,"norm_reactions":0.0526315789473684,"chokepoints":3},"properties":null,"score":0.0},{"term":"PWY-5389","name":"methylthiopropionate biosynthesis","count":1,"properties2":{"reactions":1,"completeness":1.0,"reactions_with_gene":1,"genes":1,"norm_chokepoint":1.0,"druggable":"Yes","max_centrality":9.3E-4,"norm_reactions":0.0175438596491228,"chokepoints":1},"properties":null,"score":0.0},{"term":"PWY-5837","name":"1,4-dihydroxy-2-naphthoate biosynthesis I","count":10,"properties2":{"reactions":7,"completeness":1.0,"reactions_with_gene":7,"genes":10,"norm_chokepoint":0.857142857142857,"druggable":"Yes","max_centrality":0.08735,"norm_reactions":0.12280701754386,"chokepoints":6},"properties":null,"score":0.0},{"term":"DETOX1-PWY-1","name":"superoxide radicals degradation","count":7,"properties2":{"reactions":4,"completeness":0.75,"reactions_with_gene":3,"genes":7,"norm_chokepoint":0.5,"druggable":"Yes","max_centrality":0.0,"norm_reactions":0.0701754385964912,"chokepoints":2},"properties":null,"score":0.0},{"term":"PWY-5839","name":"menaquinone-7 biosynthesis","count":2,"properties2":{"reactions":2,"completeness":1.0,"reactions_with_gene":2,"genes":2,"norm_chokepoint":1.0,"druggable":"Yes","max_centrality":0.00518673479575301,"norm_reactions":0.0350877192982456,"chokepoints":2},"properties":null,"score":0.0},{"term":"PWY-1801","name":"formaldehyde oxidation II (glutathione-dependent)","count":6,"properties2":{"reactions":4,"completeness":0.75,"reactions_with_gene":3,"genes":6,"norm_chokepoint":0.25,"druggable":"Yes","max_centrality":0.0155477661743196,"norm_reactions":0.0701754385964912,"chokepoints":1},"properties":null,"score":0.0},{"term":"P562-PWY","name":"myo-inositol degradation I","count":8,"properties2":{"reactions":7,"completeness":1.0,"reactions_with_gene":7,"genes":8,"norm_chokepoint":0.857142857142857,"druggable":"Yes","max_centrality":0.11091,"norm_reactions":0.12280701754386,"chokepoints":6},"properties":null,"score":0.0},{"term":"PWY0-781","name":"aspartate superpathway","count":36,"properties2":{"reactions":25,"completeness":1.0,"reactions_with_gene":25,"genes":36,"norm_chokepoint":0.68,"druggable":"Yes","max_centrality":0.56331,"norm_reactions":0.43859649122807,"chokepoints":17},"properties":null,"score":0.0},{"term":"LACTOSEUTIL-PWY","name":"lactose degradation II","count":2,"properties2":{"reactions":5,"completeness":0.4,"reactions_with_gene":2,"genes":2,"norm_chokepoint":0.2,"druggable":"No","max_centrality":0.014030304195706,"norm_reactions":0.087719298245614,"chokepoints":1},"properties":null,"score":0.0},{"term":"CYSTSYN-PWY","name":"cysteine biosynthesis I","count":3,"properties2":{"reactions":2,"completeness":1.0,"reactions_with_gene":2,"genes":3,"norm_chokepoint":0.5,"druggable":"Yes","max_centrality":0.30432,"norm_reactions":0.0350877192982456,"chokepoints":1},"properties":null,"score":0.0},{"term":"PWY0-1565","name":"D-lactate to cytochrome bo oxidase electron transport","count":4,"properties2":{"reactions":2,"completeness":1.0,"reactions_with_gene":2,"genes":4,"norm_chokepoint":0.5,"druggable":"Yes","max_centrality":0.0306318634107291,"norm_reactions":0.0350877192982456,"chokepoints":1},"properties":null,"score":0.0},{"term":"PWY0-1561","name":"glycerol-3-phosphate to cytochrome bo oxidase electron transfer","count":7,"properties2":{"reactions":2,"completeness":1.0,"reactions_with_gene":2,"genes":7,"norm_chokepoint":0.0,"druggable":"Yes","max_centrality":0.0306318634107291,"norm_reactions":0.0350877192982456,"chokepoints":0},"properties":null,"score":0.0},{"term":"BGALACT-PWY","name":"lactose degradation III","count":4,"properties2":{"reactions":4,"completeness":1.0,"reactions_with_gene":4,"genes":4,"norm_chokepoint":0.0,"druggable":"No","max_centrality":0.0,"norm_reactions":0.0701754385964912,"chokepoints":0},"properties":null,"score":0.0},{"term":"GLUTATHIONESYN-PWY","name":"glutathione biosynthesis","count":2,"properties2":{"reactions":2,"completeness":1.0,"reactions_with_gene":2,"genes":2,"norm_chokepoint":1.0,"druggable":"Yes","max_centrality":0.00331,"norm_reactions":0.0350877192982456,"chokepoints":2},"properties":null,"score":0.0},{"term":"PWY0-1569","name":"autoinducer AI-2 degradation","count":3,"properties2":{"reactions":3,"completeness":1.0,"reactions_with_gene":3,"genes":3,"norm_chokepoint":0.666666666666667,"druggable":"Yes","max_centrality":0.02045,"norm_reactions":0.0526315789473684,"chokepoints":2},"properties":null,"score":0.0},{"term":"ASPARAGINE-BIOSYNTHESIS","name":"asparagine biosynthesis I","count":12,"properties2":{"reactions":3,"completeness":1.0,"reactions_with_gene":3,"genes":12,"norm_chokepoint":0.0,"druggable":"Yes","max_centrality":0.26087,"norm_reactions":0.0526315789473684,"chokepoints":0},"properties":null,"score":0.0},{"term":"HEMESYN2-PWY","name":"heme biosynthesis from uroporphyrinogen-III II (anaerobic)","count":4,"properties2":{"reactions":4,"completeness":1.0,"reactions_with_gene":4,"genes":4,"norm_chokepoint":0.75,"druggable":"Yes","max_centrality":0.07419,"norm_reactions":0.0701754385964912,"chokepoints":3},"properties":null,"score":0.0},{"term":"PWY-6690","name":"cinnamate and 3-hydroxycinnamate degradation to 2-oxopent-4-enoate","count":3,"properties2":{"reactions":6,"completeness":0.5,"reactions_with_gene":3,"genes":3,"norm_chokepoint":1.0,"druggable":"Yes","max_centrality":0.0449057529100661,"norm_reactions":0.105263157894737,"chokepoints":6},"properties":null,"score":0.0},{"term":"PHESYN","name":"phenylalanine biosynthesis I","count":6,"properties2":{"reactions":3,"completeness":1.0,"reactions_with_gene":3,"genes":6,"norm_chokepoint":0.666666666666667,"druggable":"Yes","max_centrality":0.10045,"norm_reactions":0.0526315789473684,"chokepoints":2},"properties":null,"score":0.0},{"term":"PWY-7185","name":"UTP and CTP dephosphorylation I","count":23,"properties2":{"reactions":11,"completeness":0.636363636363636,"reactions_with_gene":7,"genes":23,"norm_chokepoint":0.0,"druggable":"Yes","max_centrality":0.59093,"norm_reactions":0.192982456140351,"chokepoints":0},"properties":null,"score":0.0},{"term":"PWY-7184","name":"pyrimidine deoxyribonucleotides de novo biosynthesis I","count":13,"properties2":{"reactions":9,"completeness":1.0,"reactions_with_gene":9,"genes":13,"norm_chokepoint":0.555555555555556,"druggable":"Yes","max_centrality":0.276983245712824,"norm_reactions":0.157894736842105,"chokepoints":5},"properties":null,"score":0.0},{"term":"PWY-7187","name":"pyrimidine deoxyribonucleotides de novo biosynthesis II","count":8,"properties2":{"reactions":7,"completeness":1.0,"reactions_with_gene":7,"genes":8,"norm_chokepoint":0.428571428571429,"druggable":"Yes","max_centrality":0.14956,"norm_reactions":0.12280701754386,"chokepoints":3},"properties":null,"score":0.0},{"term":"PWY-7181","name":"pyrimidine deoxyribonucleosides degradation","count":3,"properties2":{"reactions":3,"completeness":1.0,"reactions_with_gene":3,"genes":3,"norm_chokepoint":0.333333333333333,"druggable":"Yes","max_centrality":0.165261192921456,"norm_reactions":0.0526315789473684,"chokepoints":1},"properties":null,"score":0.0},{"term":"PWY-7180","name":"2'-deoxy-α-D-ribose 1-phosphate degradation","count":4,"properties2":{"reactions":3,"completeness":1.0,"reactions_with_gene":3,"genes":4,"norm_chokepoint":0.666666666666667,"druggable":"Yes","max_centrality":0.32122,"norm_reactions":0.0526315789473684,"chokepoints":2},"properties":null,"score":0.0},{"term":"PWY-7220","name":"adenosine deoxyribonucleotides de novo biosynthesis II","count":6,"properties2":{"reactions":4,"completeness":1.0,"reactions_with_gene":4,"genes":6,"norm_chokepoint":0.0,"druggable":"Yes","max_centrality":0.34351,"norm_reactions":0.0701754385964912,"chokepoints":0},"properties":null,"score":0.0},{"term":"TRPIAACAT-PWY","name":"tryptophan degradation VII (via indole-3-pyruvate)","count":2,"properties2":{"reactions":3,"completeness":0.666666666666667,"reactions_with_gene":2,"genes":2,"norm_chokepoint":0.666666666666667,"druggable":"Yes","max_centrality":0.01436,"norm_reactions":0.0526315789473684,"chokepoints":2},"properties":null,"score":0.0},{"term":"GLCMANNANAUT-PWY","name":"superpathway of N-acetylglucosamine, N-acetylmannosamine and N-acetylneuraminate degradation","count":4,"properties2":{"reactions":5,"completeness":0.6,"reactions_with_gene":3,"genes":4,"norm_chokepoint":0.8,"druggable":"Yes","max_centrality":0.06008,"norm_reactions":0.087719298245614,"chokepoints":4},"properties":null,"score":0.0},{"term":"PWY-5489","name":"methyl parathion degradation","count":1,"properties2":{"reactions":1,"completeness":1.0,"reactions_with_gene":1,"genes":1,"norm_chokepoint":1.0,"druggable":"Yes","max_centrality":0.0,"norm_reactions":0.0175438596491228,"chokepoints":1},"properties":null,"score":0.0},{"term":"GLYSYN-PWY","name":"glycine biosynthesis I","count":1,"properties2":{"reactions":1,"completeness":1.0,"reactions_with_gene":1,"genes":1,"norm_chokepoint":0.0,"druggable":"Yes","max_centrality":0.632073787311858,"norm_reactions":0.0175438596491228,"chokepoints":0},"properties":null,"score":0.0},{"term":"PWY-7227","name":"adenosine deoxyribonucleotides de novo biosynthesis","count":3,"properties2":{"reactions":2,"completeness":1.0,"reactions_with_gene":2,"genes":3,"norm_chokepoint":0.0,"druggable":"Yes","max_centrality":0.34351,"norm_reactions":0.0350877192982456,"chokepoints":0},"properties":null,"score":0.0},{"term":"PWY-6151","name":"S-adenosyl-L-methionine cycle I","count":6,"properties2":{"reactions":5,"completeness":0.8,"reactions_with_gene":4,"genes":6,"norm_chokepoint":0.8,"druggable":"Yes","max_centrality":0.56331,"norm_reactions":0.087719298245614,"chokepoints":4},"properties":null,"score":0.0},{"term":"PWY-6012","name":"acyl carrier protein metabolism I","count":2,"properties2":{"reactions":2,"completeness":1.0,"reactions_with_gene":2,"genes":2,"norm_chokepoint":1.0,"druggable":"Yes","max_centrality":8.29214195963711E-6,"norm_reactions":0.0350877192982456,"chokepoints":2},"properties":null,"score":0.0},{"term":"PWY0-1296","name":"purine ribonucleosides degradation","count":6,"properties2":{"reactions":6,"completeness":1.0,"reactions_with_gene":6,"genes":6,"norm_chokepoint":0.166666666666667,"druggable":"Yes","max_centrality":0.158207139674285,"norm_reactions":0.105263157894737,"chokepoints":1},"properties":null,"score":0.0},{"term":"PWY0-1297","name":"superpathway of purine deoxyribonucleosides degradation","count":8,"properties2":{"reactions":7,"completeness":1.0,"reactions_with_gene":7,"genes":8,"norm_chokepoint":0.714285714285714,"druggable":"Yes","max_centrality":0.32122,"norm_reactions":0.12280701754386,"chokepoints":5},"properties":null,"score":0.0},{"term":"ENTNER-DOUDOROFF-PWY","name":"Entner-Doudoroff pathway I","count":2,"properties2":{"reactions":2,"completeness":1.0,"reactions_with_gene":2,"genes":2,"norm_chokepoint":0.5,"druggable":"Yes","max_centrality":0.15854,"norm_reactions":0.0350877192982456,"chokepoints":1},"properties":null,"score":0.0},{"term":"PWY-6609","name":"adenine and adenosine salvage III","count":5,"properties2":{"reactions":4,"completeness":1.0,"reactions_with_gene":4,"genes":5,"norm_chokepoint":0.0,"druggable":"Yes","max_centrality":0.0950943002123338,"norm_reactions":0.0701754385964912,"chokepoints":0},"properties":null,"score":0.0},{"term":"PWY-6608","name":"guanosine nucleotides degradation III","count":8,"properties2":{"reactions":4,"completeness":1.0,"reactions_with_gene":4,"genes":8,"norm_chokepoint":0.25,"druggable":"Yes","max_centrality":0.136115623685863,"norm_reactions":0.0701754385964912,"chokepoints":1},"properties":null,"score":0.0},{"term":"PWY-5481","name":"pyruvate fermentation to lactate","count":1,"properties2":{"reactions":1,"completeness":1.0,"reactions_with_gene":1,"genes":1,"norm_chokepoint":0.0,"druggable":"Yes","max_centrality":0.00355,"norm_reactions":0.0175438596491228,"chokepoints":0},"properties":null,"score":0.0},{"term":"PWY0-1298","name":"superpathway of pyrimidine deoxyribonucleosides degradation","count":7,"properties2":{"reactions":6,"completeness":1.0,"reactions_with_gene":6,"genes":7,"norm_chokepoint":0.5,"druggable":"Yes","max_centrality":0.32122,"norm_reactions":0.105263157894737,"chokepoints":3},"properties":null,"score":0.0},{"term":"PWY0-1299","name":"arginine dependent acid resistance","count":1,"properties2":{"reactions":1,"completeness":1.0,"reactions_with_gene":1,"genes":1,"norm_chokepoint":1.0,"druggable":"Yes","max_centrality":0.00784,"norm_reactions":0.0175438596491228,"chokepoints":1},"properties":null,"score":0.0},{"term":"PWY-5350","name":"thiosulfate disproportionation III (rhodanese)","count":3,"properties2":{"reactions":1,"completeness":1.0,"reactions_with_gene":1,"genes":3,"norm_chokepoint":0.0,"druggable":"Yes","max_centrality":0.02398,"norm_reactions":0.0175438596491228,"chokepoints":0},"properties":null,"score":0.0},{"term":"TREDEGLOW-PWY","name":"trehalose degradation I (low osmolarity)","count":8,"properties2":{"reactions":8,"completeness":1.0,"reactions_with_gene":8,"genes":8,"norm_chokepoint":0.0,"druggable":"No","max_centrality":0.08233,"norm_reactions":0.140350877192982,"chokepoints":0},"properties":null,"score":0.0},{"term":"OXIDATIVEPENT-PWY","name":"pentose phosphate pathway (oxidative branch) I","count":4,"properties2":{"reactions":4,"completeness":1.0,"reactions_with_gene":4,"genes":4,"norm_chokepoint":0.25,"druggable":"Yes","max_centrality":0.12632,"norm_reactions":0.0701754385964912,"chokepoints":1},"properties":null,"score":0.0},{"term":"PWY0-321","name":"phenylacetate degradation I (aerobic)","count":10,"properties2":{"reactions":9,"completeness":1.0,"reactions_with_gene":9,"genes":10,"norm_chokepoint":0.888888888888889,"druggable":"Yes","max_centrality":0.086,"norm_reactions":0.157894736842105,"chokepoints":8},"properties":null,"score":0.0},{"term":"TYRSYN","name":"tyrosine biosynthesis I","count":6,"properties2":{"reactions":3,"completeness":1.0,"reactions_with_gene":3,"genes":6,"norm_chokepoint":0.333333333333333,"druggable":"Yes","max_centrality":0.10045,"norm_reactions":0.0526315789473684,"chokepoints":1},"properties":null,"score":0.0},{"term":"COBALSYN-PWY","name":"adenosylcobalamin salvage from cobinamide I","count":9,"properties2":{"reactions":6,"completeness":1.0,"reactions_with_gene":6,"genes":9,"norm_chokepoint":0.833333333333333,"druggable":"Yes","max_centrality":0.0636360521094417,"norm_reactions":0.105263157894737,"chokepoints":5},"properties":null,"score":0.0},{"term":"ACETATEUTIL-PWY","name":"superpathway of acetate utilization and formation","count":5,"properties2":{"reactions":3,"completeness":1.0,"reactions_with_gene":3,"genes":5,"norm_chokepoint":0.666666666666667,"druggable":"Yes","max_centrality":0.45671,"norm_reactions":0.0526315789473684,"chokepoints":2},"properties":null,"score":0.0},{"term":"CITRULLINE-DEG-PWY","name":"citrulline degradation","count":1,"properties2":{"reactions":2,"completeness":0.5,"reactions_with_gene":1,"genes":1,"norm_chokepoint":0.0,"druggable":"Yes","max_centrality":0.0737750560884987,"norm_reactions":0.0350877192982456,"chokepoints":0},"properties":null,"score":0.0},{"term":"PWY-7335","name":"UDP-N-acetyl-α-D-mannosaminouronate biosynthesis","count":2,"properties2":{"reactions":2,"completeness":1.0,"reactions_with_gene":2,"genes":2,"norm_chokepoint":1.0,"druggable":"Yes","max_centrality":0.00717,"norm_reactions":0.0350877192982456,"chokepoints":2},"properties":null,"score":0.0},{"term":"OANTIGEN-PWY","name":"O-antigen building blocks biosynthesis (E. coli)","count":14,"properties2":{"reactions":13,"completeness":1.0,"reactions_with_gene":13,"genes":14,"norm_chokepoint":0.769230769230769,"druggable":"Yes","max_centrality":1.0,"norm_reactions":0.228070175438596,"chokepoints":10},"properties":null,"score":0.0},{"term":"PWY-6121","name":"5-aminoimidazole ribonucleotide biosynthesis I","count":5,"properties2":{"reactions":5,"completeness":1.0,"reactions_with_gene":5,"genes":5,"norm_chokepoint":0.8,"druggable":"Yes","max_centrality":0.12427,"norm_reactions":0.087719298245614,"chokepoints":4},"properties":null,"score":0.0},{"term":"PWY-6122","name":"5-aminoimidazole ribonucleotide biosynthesis II","count":6,"properties2":{"reactions":5,"completeness":1.0,"reactions_with_gene":5,"genes":6,"norm_chokepoint":0.8,"druggable":"Yes","max_centrality":0.12427,"norm_reactions":0.087719298245614,"chokepoints":4},"properties":null,"score":0.0},{"term":"PWY-6123","name":"inosine-5'-phosphate biosynthesis I","count":6,"properties2":{"reactions":6,"completeness":1.0,"reactions_with_gene":6,"genes":6,"norm_chokepoint":1.0,"druggable":"Yes","max_centrality":0.07045,"norm_reactions":0.105263157894737,"chokepoints":6},"properties":null,"score":0.0},{"term":"PWY-6124","name":"inosine-5'-phosphate biosynthesis II","count":6,"properties2":{"reactions":5,"completeness":1.0,"reactions_with_gene":5,"genes":6,"norm_chokepoint":0.8,"druggable":"Yes","max_centrality":0.07045,"norm_reactions":0.087719298245614,"chokepoints":4},"properties":null,"score":0.0},{"term":"PWY-6125","name":"guanosine nucleotides de novo biosynthesis","count":20,"properties2":{"reactions":10,"completeness":1.0,"reactions_with_gene":10,"genes":20,"norm_chokepoint":0.1,"druggable":"Yes","max_centrality":0.26904,"norm_reactions":0.175438596491228,"chokepoints":1},"properties":null,"score":0.0},{"term":"PWY-6126","name":"adenosine nucleotides de novo biosynthesis","count":9,"properties2":{"reactions":8,"completeness":0.875,"reactions_with_gene":7,"genes":9,"norm_chokepoint":0.375,"druggable":"Yes","max_centrality":0.34351,"norm_reactions":0.140350877192982,"chokepoints":3},"properties":null,"score":0.0},{"term":"THRESYN-PWY","name":"threonine biosynthesis","count":12,"properties2":{"reactions":7,"completeness":1.0,"reactions_with_gene":7,"genes":12,"norm_chokepoint":0.571428571428571,"druggable":"Yes","max_centrality":0.05219,"norm_reactions":0.12280701754386,"chokepoints":4},"properties":null,"score":0.0},{"term":"DTDPRHAMSYN-PWY","name":"dTDP-L-rhamnose biosynthesis I","count":4,"properties2":{"reactions":4,"completeness":1.0,"reactions_with_gene":4,"genes":4,"norm_chokepoint":1.0,"druggable":"Yes","max_centrality":0.02155,"norm_reactions":0.0701754385964912,"chokepoints":4},"properties":null,"score":0.0},{"term":"PWY-7560","name":"methylerythritol phosphate pathway II","count":9,"properties2":{"reactions":9,"completeness":1.0,"reactions_with_gene":9,"genes":9,"norm_chokepoint":0.777777777777778,"druggable":"Yes","max_centrality":0.11716,"norm_reactions":0.157894736842105,"chokepoints":7},"properties":null,"score":0.0},{"term":"PWY0-1582","name":"PWY0-1582","count":9,"properties2":{"reactions":2,"completeness":1.0,"reactions_with_gene":2,"genes":9,"norm_chokepoint":0.0,"druggable":"Yes","max_centrality":0.10448565302128,"norm_reactions":0.0350877192982456,"chokepoints":0},"properties":null,"score":0.0},{"term":"PWY0-522","name":"lipoate salvage I","count":4,"properties2":{"reactions":2,"completeness":1.0,"reactions_with_gene":2,"genes":4,"norm_chokepoint":0.5,"druggable":"Yes","max_centrality":0.00396,"norm_reactions":0.0350877192982456,"chokepoints":1},"properties":null,"score":0.0},{"term":"PWY0-1586","name":"PWY0-1586","count":12,"properties2":{"reactions":11,"completeness":0.363636363636364,"reactions_with_gene":4,"genes":12,"norm_chokepoint":1.0,"druggable":"Yes","max_centrality":0.0588749899347491,"norm_reactions":0.192982456140351,"chokepoints":11},"properties":null,"score":0.0},{"term":"PWY-6902","name":"chitin degradation II","count":2,"properties2":{"reactions":2,"completeness":1.0,"reactions_with_gene":2,"genes":2,"norm_chokepoint":1.0,"druggable":"Yes","max_centrality":0.0,"norm_reactions":0.0350877192982456,"chokepoints":2},"properties":null,"score":0.0},{"term":"GALACTARDEG-PWY","name":"D-galactarate degradation I","count":4,"properties2":{"reactions":4,"completeness":1.0,"reactions_with_gene":4,"genes":4,"norm_chokepoint":0.75,"druggable":"Yes","max_centrality":0.0230810765312747,"norm_reactions":0.0701754385964912,"chokepoints":3},"properties":null,"score":0.0},{"term":"ARO-PWY","name":"chorismate biosynthesis I","count":12,"properties2":{"reactions":8,"completeness":0.875,"reactions_with_gene":7,"genes":12,"norm_chokepoint":0.75,"druggable":"Yes","max_centrality":0.298476676010974,"norm_reactions":0.140350877192982,"chokepoints":6},"properties":null,"score":0.0},{"term":"KDO-NAGLIPASYN-PWY","name":"superpathway of (KDO)2-lipid A biosynthesis","count":17,"properties2":{"reactions":17,"completeness":0.882352941176471,"reactions_with_gene":15,"genes":17,"norm_chokepoint":1.0,"druggable":"Yes","max_centrality":0.28751,"norm_reactions":0.298245614035088,"chokepoints":17},"properties":null,"score":0.0},{"term":"SO4ASSIM-PWY","name":"sulfate reduction I (assimilatory)","count":6,"properties2":{"reactions":4,"completeness":1.0,"reactions_with_gene":4,"genes":6,"norm_chokepoint":0.75,"druggable":"Yes","max_centrality":0.07159,"norm_reactions":0.0701754385964912,"chokepoints":3},"properties":null,"score":0.0},{"term":"PWY-2503","name":"benzoate degradation I (aerobic)","count":2,"properties2":{"reactions":2,"completeness":1.0,"reactions_with_gene":2,"genes":2,"norm_chokepoint":1.0,"druggable":"Yes","max_centrality":0.04062,"norm_reactions":0.0350877192982456,"chokepoints":2},"properties":null,"score":0.0},{"term":"PWY-6305","name":"putrescine biosynthesis IV","count":4,"properties2":{"reactions":4,"completeness":1.0,"reactions_with_gene":4,"genes":4,"norm_chokepoint":0.5,"druggable":"Yes","max_centrality":0.142336268263367,"norm_reactions":0.0701754385964912,"chokepoints":2},"properties":null,"score":0.0},{"term":"PWY-7206","name":"pyrimidine deoxyribonucleotides dephosphorylation","count":4,"properties2":{"reactions":3,"completeness":1.0,"reactions_with_gene":3,"genes":4,"norm_chokepoint":0.333333333333333,"druggable":"Yes","max_centrality":0.1081,"norm_reactions":0.0526315789473684,"chokepoints":1},"properties":null,"score":0.0},{"term":"PWY-7205","name":"CMP phosphorylation","count":2,"properties2":{"reactions":2,"completeness":1.0,"reactions_with_gene":2,"genes":2,"norm_chokepoint":0.0,"druggable":"Yes","max_centrality":0.23403,"norm_reactions":0.0350877192982456,"chokepoints":0},"properties":null,"score":0.0},{"term":"PWY-7200","name":"superpathway of pyrimidine deoxyribonucleoside salvage","count":8,"properties2":{"reactions":17,"completeness":0.470588235294118,"reactions_with_gene":8,"genes":8,"norm_chokepoint":0.352941176470588,"druggable":"Yes","max_centrality":0.14956,"norm_reactions":0.298245614035088,"chokepoints":6},"properties":null,"score":0.0},{"term":"GLNSYN-PWY","name":"glutamine biosynthesis I","count":1,"properties2":{"reactions":1,"completeness":1.0,"reactions_with_gene":1,"genes":1,"norm_chokepoint":0.0,"druggable":"Yes","max_centrality":0.18303,"norm_reactions":0.0175438596491228,"chokepoints":0},"properties":null,"score":0.0},{"term":"COMPLETE-ARO-PWY","name":"superpathway of phenylalanine, tyrosine, and tryptophan biosynthesis","count":30,"properties2":{"reactions":19,"completeness":0.947368421052632,"reactions_with_gene":18,"genes":30,"norm_chokepoint":0.736842105263158,"druggable":"Yes","max_centrality":0.35353,"norm_reactions":0.333333333333333,"chokepoints":14},"properties":null,"score":0.0},{"term":"UDPNAGSYN-PWY","name":"UDP-N-acetyl-D-glucosamine biosynthesis I","count":9,"properties2":{"reactions":8,"completeness":1.0,"reactions_with_gene":8,"genes":9,"norm_chokepoint":0.625,"druggable":"Yes","max_centrality":1.0,"norm_reactions":0.140350877192982,"chokepoints":5},"properties":null,"score":0.0},{"term":"PWY-5123","name":"trans, trans-farnesyl diphosphate biosynthesis I","count":3,"properties2":{"reactions":3,"completeness":1.0,"reactions_with_gene":3,"genes":3,"norm_chokepoint":0.666666666666667,"druggable":"Yes","max_centrality":0.01026,"norm_reactions":0.0526315789473684,"chokepoints":2},"properties":null,"score":0.0},{"term":"PWY-5122","name":"geranyl diphosphate biosynthesis","count":1,"properties2":{"reactions":1,"completeness":1.0,"reactions_with_gene":1,"genes":1,"norm_chokepoint":1.0,"druggable":"Yes","max_centrality":3.4550591498488E-6,"norm_reactions":0.0175438596491228,"chokepoints":1},"properties":null,"score":0.0},{"term":"PWY0-1329","name":"succinate to cytochrome bo oxidase electron transfer","count":9,"properties2":{"reactions":2,"completeness":1.0,"reactions_with_gene":2,"genes":9,"norm_chokepoint":0.0,"druggable":"Yes","max_centrality":0.0593637897949583,"norm_reactions":0.0350877192982456,"chokepoints":0},"properties":null,"score":0.0},{"term":"ANAGLYCOLYSIS-PWY","name":"glycolysis III (from glucose)","count":31,"properties2":{"reactions":16,"completeness":1.0,"reactions_with_gene":16,"genes":31,"norm_chokepoint":0.125,"druggable":"Yes","max_centrality":0.319,"norm_reactions":0.280701754385965,"chokepoints":2},"properties":null,"score":0.0},{"term":"PWY0-1324","name":"N-acetylneuraminate and N-acetylmannosamine degradation","count":1,"properties2":{"reactions":3,"completeness":0.333333333333333,"reactions_with_gene":1,"genes":1,"norm_chokepoint":1.0,"druggable":"Yes","max_centrality":0.00677,"norm_reactions":0.0526315789473684,"chokepoints":3},"properties":null,"score":0.0},{"term":"PWY0-1325","name":"superpathway of asparagine biosynthesis","count":12,"properties2":{"reactions":3,"completeness":1.0,"reactions_with_gene":3,"genes":12,"norm_chokepoint":0.0,"druggable":"Yes","max_centrality":0.26087,"norm_reactions":0.0526315789473684,"chokepoints":0},"properties":null,"score":0.0},{"term":"MANNCAT-PWY","name":"D-mannose degradation","count":1,"properties2":{"reactions":1,"completeness":1.0,"reactions_with_gene":1,"genes":1,"norm_chokepoint":1.0,"druggable":"Yes","max_centrality":0.0,"norm_reactions":0.0175438596491228,"chokepoints":1},"properties":null,"score":0.0},{"term":"DAPLYSINESYN-PWY","name":"lysine biosynthesis I","count":14,"properties2":{"reactions":9,"completeness":1.0,"reactions_with_gene":9,"genes":14,"norm_chokepoint":1.0,"druggable":"Yes","max_centrality":0.07749,"norm_reactions":0.157894736842105,"chokepoints":9},"properties":null,"score":0.0},{"term":"PWY0-981","name":"taurine degradation IV","count":1,"properties2":{"reactions":1,"completeness":1.0,"reactions_with_gene":1,"genes":1,"norm_chokepoint":1.0,"druggable":"Yes","max_centrality":0.03888,"norm_reactions":0.0175438596491228,"chokepoints":1},"properties":null,"score":0.0},{"term":"PWY-5849","name":"menaquinol-6 biosynthesis","count":1,"properties2":{"reactions":1,"completeness":1.0,"reactions_with_gene":1,"genes":1,"norm_chokepoint":1.0,"druggable":"Yes","max_centrality":0.0,"norm_reactions":0.0175438596491228,"chokepoints":1},"properties":null,"score":0.0},{"term":"NADPHOS-DEPHOS-PWY-1","name":"NAD phosphorylation and dephosphorylation","count":1,"properties2":{"reactions":2,"completeness":0.5,"reactions_with_gene":1,"genes":1,"norm_chokepoint":0.5,"druggable":"Yes","max_centrality":0.0,"norm_reactions":0.0350877192982456,"chokepoints":1},"properties":null,"score":0.0},{"term":"SERSYN-PWY","name":"serine biosynthesis","count":3,"properties2":{"reactions":3,"completeness":1.0,"reactions_with_gene":3,"genes":3,"norm_chokepoint":1.0,"druggable":"Yes","max_centrality":0.01434,"norm_reactions":0.0526315789473684,"chokepoints":3},"properties":null,"score":0.0},{"term":"MANNIDEG-PWY","name":"mannitol degradation I","count":1,"properties2":{"reactions":1,"completeness":1.0,"reactions_with_gene":1,"genes":1,"norm_chokepoint":1.0,"druggable":"Yes","max_centrality":0.0,"norm_reactions":0.0175438596491228,"chokepoints":1},"properties":null,"score":0.0},{"term":"ALL-CHORISMATE-PWY","name":"superpathway of chorismate","count":90,"properties2":{"reactions":57,"completeness":0.982456140350877,"reactions_with_gene":56,"genes":90,"norm_chokepoint":0.87719298245614,"druggable":"Yes","max_centrality":0.35353,"norm_reactions":1.0,"chokepoints":50},"properties":null,"score":0.0},{"term":"2PHENDEG-PWY","name":"phenylethylamine degradation I","count":2,"properties2":{"reactions":2,"completeness":1.0,"reactions_with_gene":2,"genes":2,"norm_chokepoint":1.0,"druggable":"Yes","max_centrality":0.01364,"norm_reactions":0.0350877192982456,"chokepoints":2},"properties":null,"score":0.0},{"term":"AST-PWY","name":"arginine degradation II (AST pathway)","count":10,"properties2":{"reactions":5,"completeness":1.0,"reactions_with_gene":5,"genes":10,"norm_chokepoint":1.0,"druggable":"Yes","max_centrality":0.01759,"norm_reactions":0.087719298245614,"chokepoints":5},"properties":null,"score":0.0},{"term":"ASPARAGINE-DEG1-PWY","name":"asparagine degradation I","count":2,"properties2":{"reactions":1,"completeness":1.0,"reactions_with_gene":1,"genes":2,"norm_chokepoint":0.0,"druggable":"Yes","max_centrality":0.05802,"norm_reactions":0.0175438596491228,"chokepoints":0},"properties":null,"score":0.0},{"term":"PWY0-1391","name":"S-methyl-5'-thioadenosine degradation IV","count":1,"properties2":{"reactions":1,"completeness":1.0,"reactions_with_gene":1,"genes":1,"norm_chokepoint":1.0,"druggable":"Yes","max_centrality":0.0847172816915065,"norm_reactions":0.0175438596491228,"chokepoints":1},"properties":null,"score":0.0},{"term":"HEME-BIOSYNTHESIS-II","name":"heme biosynthesis from uroporphyrinogen-III I","count":4,"properties2":{"reactions":4,"completeness":1.0,"reactions_with_gene":4,"genes":4,"norm_chokepoint":0.75,"druggable":"Yes","max_centrality":0.0472,"norm_reactions":0.0701754385964912,"chokepoints":3},"properties":null,"score":0.0},{"term":"THRDLCTCAT-PWY","name":"threonine degradation III (to methylglyoxal)","count":2,"properties2":{"reactions":3,"completeness":0.666666666666667,"reactions_with_gene":2,"genes":2,"norm_chokepoint":0.333333333333333,"druggable":"Yes","max_centrality":0.00985702750949737,"norm_reactions":0.0526315789473684,"chokepoints":1},"properties":null,"score":0.0},{"term":"NAGLIPASYN-PWY","name":"lipid IVA biosynthesis","count":6,"properties2":{"reactions":6,"completeness":1.0,"reactions_with_gene":6,"genes":6,"norm_chokepoint":1.0,"druggable":"Yes","max_centrality":0.28751,"norm_reactions":0.105263157894737,"chokepoints":6},"properties":null,"score":0.0},{"term":"PWY0-162","name":"pyrimidine ribonucleotides de novo biosynthesis","count":32,"properties2":{"reactions":15,"completeness":1.0,"reactions_with_gene":15,"genes":32,"norm_chokepoint":0.4,"druggable":"Yes","max_centrality":0.59093,"norm_reactions":0.263157894736842,"chokepoints":6},"properties":null,"score":0.0},{"term":"PWY0-166","name":"pyrimidine deoxyribonucleotides de novo biosynthesis I","count":20,"properties2":{"reactions":14,"completeness":1.0,"reactions_with_gene":14,"genes":20,"norm_chokepoint":0.357142857142857,"druggable":"Yes","max_centrality":0.276983245712824,"norm_reactions":0.245614035087719,"chokepoints":5},"properties":null,"score":0.0},{"term":"ALKANEMONOX-PWY","name":"two-component alkanesulfonate monooxygenase","count":10,"properties2":{"reactions":2,"completeness":1.0,"reactions_with_gene":2,"genes":10,"norm_chokepoint":0.5,"druggable":"Yes","max_centrality":0.114779554327654,"norm_reactions":0.0350877192982456,"chokepoints":1},"properties":null,"score":0.0},{"term":"LEUSYN-PWY","name":"leucine biosynthesis","count":8,"properties2":{"reactions":6,"completeness":0.833333333333333,"reactions_with_gene":5,"genes":8,"norm_chokepoint":0.833333333333333,"druggable":"Yes","max_centrality":0.05747,"norm_reactions":0.105263157894737,"chokepoints":5},"properties":null,"score":0.0},{"term":"TRPSYN-PWY","name":"tryptophan biosynthesis","count":9,"properties2":{"reactions":6,"completeness":1.0,"reactions_with_gene":6,"genes":9,"norm_chokepoint":1.0,"druggable":"Yes","max_centrality":0.35353,"norm_reactions":0.105263157894737,"chokepoints":6},"properties":null,"score":0.0},{"term":"PWY-6164","name":"3-dehydroquinate biosynthesis I","count":4,"properties2":{"reactions":2,"completeness":1.0,"reactions_with_gene":2,"genes":4,"norm_chokepoint":1.0,"druggable":"Yes","max_centrality":0.03581,"norm_reactions":0.0350877192982456,"chokepoints":2},"properties":null,"score":0.0},{"term":"PWY-6163","name":"chorismate biosynthesis from 3-dehydroquinate","count":8,"properties2":{"reactions":6,"completeness":0.833333333333333,"reactions_with_gene":5,"genes":8,"norm_chokepoint":0.666666666666667,"druggable":"Yes","max_centrality":0.298476676010974,"norm_reactions":0.105263157894737,"chokepoints":4},"properties":null,"score":0.0},{"term":"ASPARAGINESYN-PWY","name":"asparagine biosynthesis II","count":2,"properties2":{"reactions":1,"completeness":1.0,"reactions_with_gene":1,"genes":2,"norm_chokepoint":0.0,"druggable":"Yes","max_centrality":0.00214,"norm_reactions":0.0175438596491228,"chokepoints":0},"properties":null,"score":0.0},{"term":"TCA-GLYOX-BYPASS","name":"superpathway of glyoxylate bypass and TCA","count":39,"properties2":{"reactions":17,"completeness":1.0,"reactions_with_gene":17,"genes":39,"norm_chokepoint":0.647058823529412,"druggable":"Yes","max_centrality":0.284893940533509,"norm_reactions":0.298245614035088,"chokepoints":11},"properties":null,"score":0.0},{"term":"ARGSYN-PWY","name":"arginine biosynthesis I","count":27,"properties2":{"reactions":14,"completeness":1.0,"reactions_with_gene":14,"genes":27,"norm_chokepoint":0.642857142857143,"druggable":"Yes","max_centrality":0.12857,"norm_reactions":0.245614035087719,"chokepoints":9},"properties":null,"score":0.0},{"term":"PWY-6630","name":"superpathway of L-tyrosine biosynthesis","count":18,"properties2":{"reactions":11,"completeness":0.909090909090909,"reactions_with_gene":10,"genes":18,"norm_chokepoint":0.636363636363636,"druggable":"Yes","max_centrality":0.298476676010974,"norm_reactions":0.192982456140351,"chokepoints":7},"properties":null,"score":0.0},{"term":"METHIONINE-DEG1-PWY","name":"methionine degradation I (to homocysteine)","count":2,"properties2":{"reactions":3,"completeness":0.666666666666667,"reactions_with_gene":2,"genes":2,"norm_chokepoint":0.666666666666667,"druggable":"Yes","max_centrality":0.56331,"norm_reactions":0.0526315789473684,"chokepoints":2},"properties":null,"score":0.0},{"term":"1CMET2-PWY","name":"formylTHF biosynthesis","count":16,"properties2":{"reactions":11,"completeness":1.0,"reactions_with_gene":11,"genes":16,"norm_chokepoint":0.636363636363636,"druggable":"Yes","max_centrality":0.632073787311858,"norm_reactions":0.192982456140351,"chokepoints":7},"properties":null,"score":0.0},{"term":"RHAMCAT-PWY","name":"L-rhamnose degradation I","count":4,"properties2":{"reactions":5,"completeness":0.8,"reactions_with_gene":4,"genes":4,"norm_chokepoint":1.0,"druggable":"Yes","max_centrality":0.02707,"norm_reactions":0.087719298245614,"chokepoints":5},"properties":null,"score":0.0},{"term":"PWY-7242","name":"D-fructuronate degradation","count":7,"properties2":{"reactions":4,"completeness":1.0,"reactions_with_gene":4,"genes":7,"norm_chokepoint":0.75,"druggable":"Yes","max_centrality":0.15854,"norm_reactions":0.0701754385964912,"chokepoints":3},"properties":null,"score":0.0},{"term":"FUCCAT-PWY","name":"fucose degradation","count":4,"properties2":{"reactions":4,"completeness":1.0,"reactions_with_gene":4,"genes":4,"norm_chokepoint":1.0,"druggable":"Yes","max_centrality":0.02031,"norm_reactions":0.0701754385964912,"chokepoints":4},"properties":null,"score":0.0},{"term":"PWY-7247","name":"β-D-glucuronide and D-glucuronate degradation","count":1,"properties2":{"reactions":3,"completeness":0.333333333333333,"reactions_with_gene":1,"genes":1,"norm_chokepoint":1.0,"druggable":"Yes","max_centrality":0.01362,"norm_reactions":0.0526315789473684,"chokepoints":3},"properties":null,"score":0.0},{"term":"PWY-6221","name":"2-chlorobenzoate degradation","count":1,"properties2":{"reactions":1,"completeness":1.0,"reactions_with_gene":1,"genes":1,"norm_chokepoint":1.0,"druggable":"Yes","max_centrality":0.0,"norm_reactions":0.0175438596491228,"chokepoints":1},"properties":null,"score":0.0},{"term":"PWY-1881","name":"formate oxidation to CO2","count":4,"properties2":{"reactions":1,"completeness":1.0,"reactions_with_gene":1,"genes":4,"norm_chokepoint":0.0,"druggable":"No","max_centrality":0.0,"norm_reactions":0.0175438596491228,"chokepoints":0},"properties":null,"score":0.0},{"term":"PWY-5939","name":"acetoin biosynthesis II","count":9,"properties2":{"reactions":2,"completeness":1.0,"reactions_with_gene":2,"genes":9,"norm_chokepoint":1.0,"druggable":"Yes","max_centrality":0.03587,"norm_reactions":0.0350877192982456,"chokepoints":2},"properties":null,"score":0.0},{"term":"PWY-5785","name":"di-trans,poly-cis-undecaprenyl phosphate biosynthesis","count":3,"properties2":{"reactions":2,"completeness":1.0,"reactions_with_gene":2,"genes":3,"norm_chokepoint":0.5,"druggable":"Yes","max_centrality":0.23254,"norm_reactions":0.0350877192982456,"chokepoints":1},"properties":null,"score":0.0},{"term":"PWY-5783","name":"octaprenyl diphosphate biosynthesis","count":1,"properties2":{"reactions":1,"completeness":1.0,"reactions_with_gene":1,"genes":1,"norm_chokepoint":1.0,"druggable":"Yes","max_centrality":0.116477620429252,"norm_reactions":0.0175438596491228,"chokepoints":1},"properties":null,"score":0.0},{"term":"PWY0-1471","name":"uracil degradation III","count":3,"properties2":{"reactions":6,"completeness":0.5,"reactions_with_gene":3,"genes":3,"norm_chokepoint":0.666666666666667,"druggable":"Yes","max_centrality":0.0490503968576646,"norm_reactions":0.105263157894737,"chokepoints":4},"properties":null,"score":0.0},{"term":"ALANINE-VALINESYN-PWY","name":"alanine biosynthesis I","count":4,"properties2":{"reactions":3,"completeness":1.0,"reactions_with_gene":3,"genes":4,"norm_chokepoint":0.333333333333333,"druggable":"Yes","max_centrality":0.15258,"norm_reactions":0.0526315789473684,"chokepoints":1},"properties":null,"score":0.0},{"term":"PWY0-1477","name":"ethanolamine utilization","count":4,"properties2":{"reactions":1,"completeness":1.0,"reactions_with_gene":1,"genes":4,"norm_chokepoint":1.0,"druggable":"Yes","max_centrality":0.01026,"norm_reactions":0.0175438596491228,"chokepoints":1},"properties":null,"score":0.0},{"term":"LIPASYN-PWY","name":"phospholipases","count":2,"properties2":{"reactions":5,"completeness":0.4,"reactions_with_gene":2,"genes":2,"norm_chokepoint":0.6,"druggable":"Yes","max_centrality":0.0,"norm_reactions":0.087719298245614,"chokepoints":3},"properties":null,"score":0.0},{"term":"TCA","name":"TCA cycle","count":37,"properties2":{"reactions":15,"completeness":1.0,"reactions_with_gene":15,"genes":37,"norm_chokepoint":0.666666666666667,"druggable":"Yes","max_centrality":0.284893940533509,"norm_reactions":0.263157894736842,"chokepoints":10},"properties":null,"score":0.0},{"term":"PWY-5162","name":"2-oxopentenoate degradation","count":3,"properties2":{"reactions":3,"completeness":1.0,"reactions_with_gene":3,"genes":3,"norm_chokepoint":0.333333333333333,"druggable":"Yes","max_centrality":0.32122,"norm_reactions":0.0526315789473684,"chokepoints":1},"properties":null,"score":0.0},{"term":"PWY-6894","name":"thiamin diphosphate biosynthesis I (E. coli)","count":2,"properties2":{"reactions":2,"completeness":1.0,"reactions_with_gene":2,"genes":2,"norm_chokepoint":1.0,"druggable":"Yes","max_centrality":0.06573,"norm_reactions":0.0350877192982456,"chokepoints":2},"properties":null,"score":0.0},{"term":"PWY-6896","name":"thiamin salvage I","count":2,"properties2":{"reactions":2,"completeness":1.0,"reactions_with_gene":2,"genes":2,"norm_chokepoint":1.0,"druggable":"Yes","max_centrality":0.06573,"norm_reactions":0.0350877192982456,"chokepoints":2},"properties":null,"score":0.0},{"term":"PWY-6897","name":"thiamin salvage II","count":5,"properties2":{"reactions":5,"completeness":1.0,"reactions_with_gene":5,"genes":5,"norm_chokepoint":1.0,"druggable":"Yes","max_centrality":0.06573,"norm_reactions":0.087719298245614,"chokepoints":5},"properties":null,"score":0.0},{"term":"PWY-6890","name":"4-amino-2-methyl-5-diphosphomethylpyrimidine biosynthesis","count":2,"properties2":{"reactions":2,"completeness":1.0,"reactions_with_gene":2,"genes":2,"norm_chokepoint":0.5,"druggable":"Yes","max_centrality":0.05776,"norm_reactions":0.0350877192982456,"chokepoints":1},"properties":null,"score":0.0},{"term":"PWY-6892","name":"thiazole biosynthesis I (E. coli)","count":7,"properties2":{"reactions":7,"completeness":1.0,"reactions_with_gene":7,"genes":7,"norm_chokepoint":0.857142857142857,"druggable":"Yes","max_centrality":0.10271,"norm_reactions":0.12280701754386,"chokepoints":6},"properties":null,"score":0.0},{"term":"PWY-6893","name":"thiamin diphosphate biosynthesis II (Bacillus)","count":2,"properties2":{"reactions":2,"completeness":1.0,"reactions_with_gene":2,"genes":2,"norm_chokepoint":1.0,"druggable":"Yes","max_centrality":0.06573,"norm_reactions":0.0350877192982456,"chokepoints":2},"properties":null,"score":0.0},{"term":"GALACTUROCAT-PWY","name":"D-galacturonate degradation I","count":6,"properties2":{"reactions":5,"completeness":1.0,"reactions_with_gene":5,"genes":6,"norm_chokepoint":0.8,"druggable":"Yes","max_centrality":0.15854,"norm_reactions":0.087719298245614,"chokepoints":4},"properties":null,"score":0.0},{"term":"PWY-6353","name":"purine nucleotides degradation II (aerobic)","count":20,"properties2":{"reactions":11,"completeness":1.0,"reactions_with_gene":11,"genes":20,"norm_chokepoint":0.272727272727273,"druggable":"Yes","max_centrality":0.136115623685863,"norm_reactions":0.192982456140351,"chokepoints":3},"properties":null,"score":0.0},{"term":"P2-PWY","name":"citrate lyase activation","count":2,"properties2":{"reactions":5,"completeness":0.4,"reactions_with_gene":2,"genes":2,"norm_chokepoint":0.8,"druggable":"No","max_centrality":0.0667845230174446,"norm_reactions":0.087719298245614,"chokepoints":4},"properties":null,"score":0.0},{"term":"PWY66-21","name":"ethanol degradation II (cytosol)","count":8,"properties2":{"reactions":3,"completeness":1.0,"reactions_with_gene":3,"genes":8,"norm_chokepoint":0.0,"druggable":"Yes","max_centrality":0.45671,"norm_reactions":0.0526315789473684,"chokepoints":0},"properties":null,"score":0.0},{"term":"ASPASN-PWY","name":"superpathway of aspartate and asparagine biosynthesis; interconversion of aspartate and asparagine","count":6,"properties2":{"reactions":4,"completeness":1.0,"reactions_with_gene":4,"genes":6,"norm_chokepoint":0.0,"druggable":"Yes","max_centrality":0.05802,"norm_reactions":0.0701754385964912,"chokepoints":0},"properties":null,"score":0.0},{"term":"GOLPDLCAT-PWY","name":"superpathway of glycerol degradation to 1,3-propanediol","count":7,"properties2":{"reactions":4,"completeness":1.0,"reactions_with_gene":4,"genes":7,"norm_chokepoint":0.5,"druggable":"Yes","max_centrality":0.02794,"norm_reactions":0.0701754385964912,"chokepoints":2},"properties":null,"score":0.0},{"term":"PWY0-1355","name":"formate to trimethylamine N-oxide electron transfer","count":3,"properties2":{"reactions":2,"completeness":1.0,"reactions_with_gene":2,"genes":3,"norm_chokepoint":1.0,"druggable":"Yes","max_centrality":0.0504480881828439,"norm_reactions":0.0350877192982456,"chokepoints":2},"properties":null,"score":0.0},{"term":"PANTOSYN-PWY","name":"pantothenate and coenzyme A biosynthesis I","count":10,"properties2":{"reactions":9,"completeness":1.0,"reactions_with_gene":9,"genes":10,"norm_chokepoint":0.777777777777778,"druggable":"Yes","max_centrality":0.126444331147014,"norm_reactions":0.157894736842105,"chokepoints":7},"properties":null,"score":0.0},{"term":"PWY0-1353","name":"succinate to cytochrome bd oxidase electron transfer","count":11,"properties2":{"reactions":2,"completeness":1.0,"reactions_with_gene":2,"genes":11,"norm_chokepoint":0.0,"druggable":"Yes","max_centrality":0.0593637897949583,"norm_reactions":0.0350877192982456,"chokepoints":0},"properties":null,"score":0.0},{"term":"PWY-7176","name":"UTP and CTP de novo biosynthesis","count":16,"properties2":{"reactions":5,"completeness":1.0,"reactions_with_gene":5,"genes":16,"norm_chokepoint":0.0,"druggable":"Yes","max_centrality":0.59093,"norm_reactions":0.087719298245614,"chokepoints":0},"properties":null,"score":0.0},{"term":"PWY-7179","name":"purine deoxyribonucleosides degradation","count":4,"properties2":{"reactions":4,"completeness":1.0,"reactions_with_gene":4,"genes":4,"norm_chokepoint":0.75,"druggable":"Yes","max_centrality":0.232867338425455,"norm_reactions":0.0701754385964912,"chokepoints":3},"properties":null,"score":0.0},{"term":"PWY-6901","name":"glucose and xylose degradation","count":43,"properties2":{"reactions":19,"completeness":1.0,"reactions_with_gene":19,"genes":43,"norm_chokepoint":0.263157894736842,"druggable":"Yes","max_centrality":0.207716187082672,"norm_reactions":0.333333333333333,"chokepoints":5},"properties":null,"score":0.0},{"term":"PWY0-662","name":"PRPP biosynthesis I","count":1,"properties2":{"reactions":1,"completeness":1.0,"reactions_with_gene":1,"genes":1,"norm_chokepoint":0.0,"druggable":"Yes","max_centrality":0.0992190184919193,"norm_reactions":0.0175438596491228,"chokepoints":0},"properties":null,"score":0.0},{"term":"PWY0-661","name":"PRPP biosynthesis II","count":2,"properties2":{"reactions":3,"completeness":0.666666666666667,"reactions_with_gene":2,"genes":2,"norm_chokepoint":0.666666666666667,"druggable":"Yes","max_centrality":0.158207139674285,"norm_reactions":0.0526315789473684,"chokepoints":2},"properties":null,"score":0.0},{"term":"PHOSPHONOTASE-PWY","name":"phosphonate degradation","count":3,"properties2":{"reactions":3,"completeness":1.0,"reactions_with_gene":3,"genes":3,"norm_chokepoint":0.666666666666667,"druggable":"Yes","max_centrality":0.32122,"norm_reactions":0.0526315789473684,"chokepoints":2},"properties":null,"score":0.0},{"term":"PENTOSE-P-PWY","name":"pentose phosphate pathway","count":24,"properties2":{"reactions":9,"completeness":1.0,"reactions_with_gene":9,"genes":24,"norm_chokepoint":0.222222222222222,"druggable":"Yes","max_centrality":0.172972369877888,"norm_reactions":0.157894736842105,"chokepoints":2},"properties":null,"score":0.0},{"term":"GLUTORN-PWY","name":"ornithine biosynthesis","count":5,"properties2":{"reactions":5,"completeness":1.0,"reactions_with_gene":5,"genes":5,"norm_chokepoint":1.0,"druggable":"Yes","max_centrality":0.02865,"norm_reactions":0.087719298245614,"chokepoints":5},"properties":null,"score":0.0},{"term":"PRPP-PWY","name":"superpathway of histidine, purine, and pyrimidine biosynthesis","count":80,"properties2":{"reactions":57,"completeness":0.964912280701754,"reactions_with_gene":55,"genes":80,"norm_chokepoint":0.56140350877193,"druggable":"Yes","max_centrality":0.59093,"norm_reactions":1.0,"chokepoints":32},"properties":null,"score":0.0},{"term":"POLYISOPRENSYN-PWY","name":"polyisoprenoid biosynthesis (E. coli)","count":7,"properties2":{"reactions":6,"completeness":1.0,"reactions_with_gene":6,"genes":7,"norm_chokepoint":0.666666666666667,"druggable":"Yes","max_centrality":0.23254,"norm_reactions":0.105263157894737,"chokepoints":4},"properties":null,"score":0.0},{"term":"PWY-6910","name":"hydroxymethylpyrimidine salvage","count":2,"properties2":{"reactions":2,"completeness":1.0,"reactions_with_gene":2,"genes":2,"norm_chokepoint":1.0,"druggable":"Yes","max_centrality":0.02296,"norm_reactions":0.0350877192982456,"chokepoints":2},"properties":null,"score":0.0},{"term":"PWY0-1507","name":"biotin biosynthesis from 8-amino-7-oxononanoate I","count":4,"properties2":{"reactions":3,"completeness":1.0,"reactions_with_gene":3,"genes":4,"norm_chokepoint":1.0,"druggable":"Yes","max_centrality":0.22137,"norm_reactions":0.0526315789473684,"chokepoints":3},"properties":null,"score":0.0},{"term":"GLUAMCAT-PWY","name":"N-acetylglucosamine degradation I","count":3,"properties2":{"reactions":2,"completeness":1.0,"reactions_with_gene":2,"genes":3,"norm_chokepoint":0.5,"druggable":"Yes","max_centrality":0.06008,"norm_reactions":0.0350877192982456,"chokepoints":1},"properties":null,"score":0.0},{"term":"PWY-6771","name":"rhamnogalacturonan type I degradation II (bacteria)","count":1,"properties2":{"reactions":1,"completeness":1.0,"reactions_with_gene":1,"genes":1,"norm_chokepoint":1.0,"druggable":"Yes","max_centrality":0.0,"norm_reactions":0.0175438596491228,"chokepoints":1},"properties":null,"score":0.0},{"term":"VALSYN-PWY","name":"valine biosynthesis","count":11,"properties2":{"reactions":4,"completeness":1.0,"reactions_with_gene":4,"genes":11,"norm_chokepoint":1.0,"druggable":"Yes","max_centrality":0.03587,"norm_reactions":0.0701754385964912,"chokepoints":4},"properties":null,"score":0.0},{"term":"PWY-6579","name":"superpathway of guanine and guanosine salvage","count":4,"properties2":{"reactions":3,"completeness":1.0,"reactions_with_gene":3,"genes":4,"norm_chokepoint":0.0,"druggable":"Yes","max_centrality":0.106984977148501,"norm_reactions":0.0526315789473684,"chokepoints":0},"properties":null,"score":0.0},{"term":"GLUCOSE1PMETAB-PWY","name":"glucose and glucose-1-phosphate degradation","count":14,"properties2":{"reactions":13,"completeness":0.923076923076923,"reactions_with_gene":12,"genes":14,"norm_chokepoint":0.230769230769231,"druggable":"Yes","max_centrality":0.11027,"norm_reactions":0.228070175438596,"chokepoints":3},"properties":null,"score":0.0},{"term":"PWY-4261","name":"glycerol degradation IV","count":6,"properties2":{"reactions":2,"completeness":1.0,"reactions_with_gene":2,"genes":6,"norm_chokepoint":0.0,"druggable":"Yes","max_centrality":1.50295073018423E-4,"norm_reactions":0.0350877192982456,"chokepoints":0},"properties":null,"score":0.0},{"term":"GLUTAMATE-DEG1-PWY","name":"glutamate degradation I","count":1,"properties2":{"reactions":1,"completeness":1.0,"reactions_with_gene":1,"genes":1,"norm_chokepoint":0.0,"druggable":"Yes","max_centrality":0.0,"norm_reactions":0.0175438596491228,"chokepoints":0},"properties":null,"score":0.0},{"term":"PWY-5347","name":"superpathway of methionine biosynthesis (transsulfuration)","count":18,"properties2":{"reactions":9,"completeness":1.0,"reactions_with_gene":9,"genes":18,"norm_chokepoint":0.444444444444444,"druggable":"Yes","max_centrality":0.518882338645114,"norm_reactions":0.157894736842105,"chokepoints":4},"properties":null,"score":0.0},{"term":"PWY-5437","name":"threonine degradation I","count":8,"properties2":{"reactions":6,"completeness":0.666666666666667,"reactions_with_gene":4,"genes":8,"norm_chokepoint":0.833333333333333,"druggable":"Yes","max_centrality":0.130187636509345,"norm_reactions":0.105263157894737,"chokepoints":5},"properties":null,"score":0.0},{"term":"PWY-5436","name":"threonine degradation IV","count":2,"properties2":{"reactions":2,"completeness":1.0,"reactions_with_gene":2,"genes":2,"norm_chokepoint":0.0,"druggable":"Yes","max_centrality":0.32122,"norm_reactions":0.0350877192982456,"chokepoints":0},"properties":null,"score":0.0},{"term":"LIPA-CORESYN-PWY","name":"Lipid A-core biosynthesis","count":4,"properties2":{"reactions":10,"completeness":0.4,"reactions_with_gene":4,"genes":4,"norm_chokepoint":1.0,"druggable":"Yes","max_centrality":0.086644242096992,"norm_reactions":0.175438596491228,"chokepoints":10},"properties":null,"score":0.0},{"term":"PWY-4121","name":"glutathionylspermidine biosynthesis","count":2,"properties2":{"reactions":1,"completeness":1.0,"reactions_with_gene":1,"genes":2,"norm_chokepoint":1.0,"druggable":"Yes","max_centrality":0.00359,"norm_reactions":0.0175438596491228,"chokepoints":1},"properties":null,"score":0.0},{"term":"PUTDEG-PWY","name":"putrescine degradation I","count":2,"properties2":{"reactions":2,"completeness":1.0,"reactions_with_gene":2,"genes":2,"norm_chokepoint":0.5,"druggable":"Yes","max_centrality":0.01568,"norm_reactions":0.0350877192982456,"chokepoints":1},"properties":null,"score":0.0},{"term":"PWY-5973","name":"cis-vaccenate biosynthesis","count":7,"properties2":{"reactions":5,"completeness":0.8,"reactions_with_gene":4,"genes":7,"norm_chokepoint":1.0,"druggable":"Yes","max_centrality":0.02892,"norm_reactions":0.087719298245614,"chokepoints":5},"properties":null,"score":0.0},{"term":"PWY-5971","name":"palmitate biosynthesis II (bacteria and plants)","count":51,"properties2":{"reactions":31,"completeness":0.935483870967742,"reactions_with_gene":29,"genes":51,"norm_chokepoint":0.548387096774194,"druggable":"Yes","max_centrality":0.159814451988086,"norm_reactions":0.543859649122807,"chokepoints":17},"properties":null,"score":0.0},{"term":"PWY0-845","name":"superpathway of pyridoxal 5'-phosphate biosynthesis and salvage","count":16,"properties2":{"reactions":12,"completeness":0.916666666666667,"reactions_with_gene":11,"genes":16,"norm_chokepoint":0.916666666666667,"druggable":"Yes","max_centrality":0.09873,"norm_reactions":0.210526315789474,"chokepoints":11},"properties":null,"score":0.0},{"term":"PWY-6131","name":"glycerol degradation II","count":3,"properties2":{"reactions":2,"completeness":1.0,"reactions_with_gene":2,"genes":3,"norm_chokepoint":0.5,"druggable":"Yes","max_centrality":0.02794,"norm_reactions":0.0350877192982456,"chokepoints":1},"properties":null,"score":0.0},{"term":"PWY-6130","name":"glycerol degradation III","count":4,"properties2":{"reactions":2,"completeness":1.0,"reactions_with_gene":2,"genes":4,"norm_chokepoint":0.5,"druggable":"Yes","max_centrality":1.0E-5,"norm_reactions":0.0350877192982456,"chokepoints":1},"properties":null,"score":0.0},{"term":"PWY-6708","name":"ubiquinol-8 biosynthesis (prokaryotic)","count":9,"properties2":{"reactions":8,"completeness":1.0,"reactions_with_gene":8,"genes":9,"norm_chokepoint":1.0,"druggable":"Yes","max_centrality":0.0363071435702711,"norm_reactions":0.140350877192982,"chokepoints":8},"properties":null,"score":0.0},{"term":"HOMOSER-METSYN-PWY","name":"methionine biosynthesis I","count":8,"properties2":{"reactions":4,"completeness":1.0,"reactions_with_gene":4,"genes":8,"norm_chokepoint":0.5,"druggable":"Yes","max_centrality":0.518882338645114,"norm_reactions":0.0701754385964912,"chokepoints":2},"properties":null,"score":0.0},{"term":"PWY0-1433","name":"tetrahydromonapterin biosynthesis","count":3,"properties2":{"reactions":4,"completeness":0.75,"reactions_with_gene":3,"genes":3,"norm_chokepoint":1.0,"druggable":"Yes","max_centrality":0.181017206308722,"norm_reactions":0.0701754385964912,"chokepoints":4},"properties":null,"score":0.0},{"term":"PWY-5509","name":"adenosylcobalamin biosynthesis from cobyrinate a,c-diamide I","count":8,"properties2":{"reactions":8,"completeness":0.875,"reactions_with_gene":7,"genes":8,"norm_chokepoint":1.0,"druggable":"Yes","max_centrality":0.09038,"norm_reactions":0.140350877192982,"chokepoints":8},"properties":null,"score":0.0},{"term":"PWY-5508","name":"adenosylcobalamin biosynthesis from cobyrinate a,c-diamide II","count":8,"properties2":{"reactions":9,"completeness":0.777777777777778,"reactions_with_gene":7,"genes":8,"norm_chokepoint":0.888888888888889,"druggable":"Yes","max_centrality":0.09038,"norm_reactions":0.157894736842105,"chokepoints":8},"properties":null,"score":0.0},{"term":"PWY-6700","name":"queuosine biosynthesis","count":5,"properties2":{"reactions":4,"completeness":1.0,"reactions_with_gene":4,"genes":5,"norm_chokepoint":1.0,"druggable":"Yes","max_centrality":0.13463,"norm_reactions":0.0701754385964912,"chokepoints":4},"properties":null,"score":0.0},{"term":"PWY-6703","name":"preQ0 biosynthesis","count":4,"properties2":{"reactions":4,"completeness":1.0,"reactions_with_gene":4,"genes":4,"norm_chokepoint":1.0,"druggable":"Yes","max_centrality":0.181017206308722,"norm_reactions":0.0701754385964912,"chokepoints":4},"properties":null,"score":0.0},{"term":"GLUT-REDOX-PWY","name":"glutathione redox reactions II","count":1,"properties2":{"reactions":3,"completeness":0.333333333333333,"reactions_with_gene":1,"genes":1,"norm_chokepoint":0.666666666666667,"druggable":"Yes","max_centrality":0.0371704355077032,"norm_reactions":0.0526315789473684,"chokepoints":2},"properties":null,"score":0.0},{"term":"FAO-PWY","name":"fatty acid β-oxidation I","count":92,"properties2":{"reactions":38,"completeness":1.0,"reactions_with_gene":38,"genes":92,"norm_chokepoint":0.736842105263158,"druggable":"No","max_centrality":0.185855923812326,"norm_reactions":0.666666666666667,"chokepoints":28},"properties":null,"score":0.0},{"term":"PROSYN-PWY","name":"proline biosynthesis I","count":4,"properties2":{"reactions":5,"completeness":0.8,"reactions_with_gene":4,"genes":4,"norm_chokepoint":0.4,"druggable":"Yes","max_centrality":0.05016,"norm_reactions":0.087719298245614,"chokepoints":2},"properties":null,"score":0.0},{"term":"SALVADEHYPOX-PWY","name":"adenosine nucleotides degradation II","count":9,"properties2":{"reactions":5,"completeness":1.0,"reactions_with_gene":5,"genes":9,"norm_chokepoint":0.2,"druggable":"Yes","max_centrality":0.0405901696106878,"norm_reactions":0.087719298245614,"chokepoints":1},"properties":null,"score":0.0},{"term":"PWY0-901","name":"selenocysteine biosynthesis I (bacteria)","count":3,"properties2":{"reactions":3,"completeness":1.0,"reactions_with_gene":3,"genes":3,"norm_chokepoint":1.0,"druggable":"Yes","max_centrality":0.00689598157809638,"norm_reactions":0.0526315789473684,"chokepoints":3},"properties":null,"score":0.0},{"term":"PWY-6617","name":"adenosine nucleotides degradation III","count":2,"properties2":{"reactions":2,"completeness":1.0,"reactions_with_gene":2,"genes":2,"norm_chokepoint":0.0,"druggable":"No","max_centrality":0.0,"norm_reactions":0.0350877192982456,"chokepoints":0},"properties":null,"score":0.0},{"term":"GLUCARDEG-PWY","name":"D-glucarate degradation I","count":5,"properties2":{"reactions":4,"completeness":1.0,"reactions_with_gene":4,"genes":5,"norm_chokepoint":0.75,"druggable":"Yes","max_centrality":0.0230810765312747,"norm_reactions":0.0701754385964912,"chokepoints":3},"properties":null,"score":0.0},{"term":"PWY-5485","name":"pyruvate fermentation to acetate IV","count":7,"properties2":{"reactions":3,"completeness":1.0,"reactions_with_gene":3,"genes":7,"norm_chokepoint":0.666666666666667,"druggable":"Yes","max_centrality":0.6249,"norm_reactions":0.0526315789473684,"chokepoints":2},"properties":null,"score":0.0},{"term":"P121-PWY","name":"salvage pathways of purine nucleosides I","count":2,"properties2":{"reactions":2,"completeness":1.0,"reactions_with_gene":2,"genes":2,"norm_chokepoint":0.0,"druggable":"Yes","max_centrality":0.0950943002123338,"norm_reactions":0.0350877192982456,"chokepoints":0},"properties":null,"score":0.0},{"term":"PWY-5480","name":"pyruvate fermentation to ethanol I","count":8,"properties2":{"reactions":3,"completeness":1.0,"reactions_with_gene":3,"genes":8,"norm_chokepoint":0.0,"druggable":"Yes","max_centrality":0.6249,"norm_reactions":0.0526315789473684,"chokepoints":0},"properties":null,"score":0.0},{"term":"PWY4FS-7","name":"phosphatidylglycerol biosynthesis I (plastidic)","count":6,"properties2":{"reactions":5,"completeness":1.0,"reactions_with_gene":5,"genes":6,"norm_chokepoint":0.8,"druggable":"No","max_centrality":0.284230227253626,"norm_reactions":0.087719298245614,"chokepoints":4},"properties":null,"score":0.0},{"term":"PWY-7211","name":"superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis","count":45,"properties2":{"reactions":24,"completeness":1.0,"reactions_with_gene":24,"genes":45,"norm_chokepoint":0.458333333333333,"druggable":"Yes","max_centrality":0.59093,"norm_reactions":0.421052631578947,"chokepoints":11},"properties":null,"score":0.0},{"term":"PWY-7219","name":"adenosine ribonucleotides de novo biosynthesis","count":3,"properties2":{"reactions":4,"completeness":0.75,"reactions_with_gene":3,"genes":3,"norm_chokepoint":0.75,"druggable":"Yes","max_centrality":0.155116462498488,"norm_reactions":0.0701754385964912,"chokepoints":3},"properties":null,"score":0.0},{"term":"PWY-6613","name":"tetrahydrofolate salvage from 5,10-methenyltetrahydrofolate","count":2,"properties2":{"reactions":2,"completeness":1.0,"reactions_with_gene":2,"genes":2,"norm_chokepoint":0.5,"druggable":"Yes","max_centrality":0.04049,"norm_reactions":0.0350877192982456,"chokepoints":1},"properties":null,"score":0.0},{"term":"METSYN-PWY","name":"homoserine and methionine biosynthesis","count":17,"properties2":{"reactions":8,"completeness":1.0,"reactions_with_gene":8,"genes":17,"norm_chokepoint":0.5,"druggable":"Yes","max_centrality":0.518882338645114,"norm_reactions":0.140350877192982,"chokepoints":4},"properties":null,"score":0.0},{"term":"DETOX1-PWY","name":"superoxide radicals degradation","count":6,"properties2":{"reactions":2,"completeness":1.0,"reactions_with_gene":2,"genes":6,"norm_chokepoint":0.5,"druggable":"Yes","max_centrality":0.0,"norm_reactions":0.0350877192982456,"chokepoints":1},"properties":null,"score":0.0},{"term":"PWY-6823","name":"molybdenum cofactor biosynthesis","count":8,"properties2":{"reactions":7,"completeness":1.0,"reactions_with_gene":7,"genes":8,"norm_chokepoint":1.0,"druggable":"Yes","max_centrality":0.10271,"norm_reactions":0.12280701754386,"chokepoints":7},"properties":null,"score":0.0},{"term":"PWY4FS-8","name":"phosphatidylglycerol biosynthesis II (non-plastidic)","count":9,"properties2":{"reactions":6,"completeness":1.0,"reactions_with_gene":6,"genes":9,"norm_chokepoint":0.333333333333333,"druggable":"No","max_centrality":0.284230227253626,"norm_reactions":0.105263157894737,"chokepoints":2},"properties":null,"score":0.0},{"term":"HISDEG-PWY","name":"histidine degradation I","count":4,"properties2":{"reactions":4,"completeness":1.0,"reactions_with_gene":4,"genes":4,"norm_chokepoint":1.0,"druggable":"Yes","max_centrality":0.09032,"norm_reactions":0.0701754385964912,"chokepoints":4},"properties":null,"score":0.0},{"term":"PWY-6268","name":"adenosylcobalamin salvage from cobalamin","count":1,"properties2":{"reactions":1,"completeness":1.0,"reactions_with_gene":1,"genes":1,"norm_chokepoint":1.0,"druggable":"Yes","max_centrality":0.0,"norm_reactions":0.0175438596491228,"chokepoints":1},"properties":null,"score":0.0},{"term":"PWY0-44","name":"D-allose degradation","count":4,"properties2":{"reactions":3,"completeness":1.0,"reactions_with_gene":3,"genes":4,"norm_chokepoint":1.0,"druggable":"Yes","max_centrality":0.02031,"norm_reactions":0.0526315789473684,"chokepoints":3},"properties":null,"score":0.0},{"term":"PWY0-1313","name":"acetate conversion to acetyl-CoA","count":1,"properties2":{"reactions":1,"completeness":1.0,"reactions_with_gene":1,"genes":1,"norm_chokepoint":0.0,"druggable":"Yes","max_centrality":0.45671,"norm_reactions":0.0175438596491228,"chokepoints":0},"properties":null,"score":0.0},{"term":"PWY0-1312","name":"acetate formation from acetyl-CoA I","count":4,"properties2":{"reactions":2,"completeness":1.0,"reactions_with_gene":2,"genes":4,"norm_chokepoint":1.0,"druggable":"Yes","max_centrality":0.00717,"norm_reactions":0.0350877192982456,"chokepoints":2},"properties":null,"score":0.0},{"term":"PWY0-1315","name":"L-lactaldehyde degradation (anaerobic)","count":1,"properties2":{"reactions":1,"completeness":1.0,"reactions_with_gene":1,"genes":1,"norm_chokepoint":1.0,"druggable":"Yes","max_centrality":0.0444602830449532,"norm_reactions":0.0175438596491228,"chokepoints":1},"properties":null,"score":0.0},{"term":"PWY0-1314","name":"fructose degradation","count":1,"properties2":{"reactions":1,"completeness":1.0,"reactions_with_gene":1,"genes":1,"norm_chokepoint":0.0,"druggable":"Yes","max_centrality":0.00115,"norm_reactions":0.0175438596491228,"chokepoints":0},"properties":null,"score":0.0},{"term":"PWY-5653","name":"NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde","count":3,"properties2":{"reactions":4,"completeness":0.75,"reactions_with_gene":3,"genes":3,"norm_chokepoint":0.75,"druggable":"Yes","max_centrality":0.07011,"norm_reactions":0.0701754385964912,"chokepoints":3},"properties":null,"score":0.0},{"term":"NADPHOS-DEPHOS-PWY","name":"NAD phosphorylation and dephosphorylation I","count":4,"properties2":{"reactions":3,"completeness":0.666666666666667,"reactions_with_gene":2,"genes":4,"norm_chokepoint":0.333333333333333,"druggable":"Yes","max_centrality":0.0,"norm_reactions":0.0526315789473684,"chokepoints":1},"properties":null,"score":0.0},{"term":"UBISYN-PWY","name":"ubiquinol-8 biosynthesis (prokaryotic)","count":10,"properties2":{"reactions":9,"completeness":1.0,"reactions_with_gene":9,"genes":10,"norm_chokepoint":1.0,"druggable":"Yes","max_centrality":0.116477620429252,"norm_reactions":0.157894736842105,"chokepoints":9},"properties":null,"score":0.0},{"term":"PWY-6406","name":"salicylate biosynthesis I","count":4,"properties2":{"reactions":2,"completeness":1.0,"reactions_with_gene":2,"genes":4,"norm_chokepoint":0.5,"druggable":"Yes","max_centrality":0.0772045608707471,"norm_reactions":0.0350877192982456,"chokepoints":1},"properties":null,"score":0.0},{"term":"HOMOSER-THRESYN-PWY","name":"threonine biosynthesis from homoserine","count":2,"properties2":{"reactions":2,"completeness":1.0,"reactions_with_gene":2,"genes":2,"norm_chokepoint":1.0,"druggable":"Yes","max_centrality":0.01632,"norm_reactions":0.0350877192982456,"chokepoints":2},"properties":null,"score":0.0},{"term":"PWY-5851","name":"demethylmenaquinol-9 biosynthesis","count":1,"properties2":{"reactions":1,"completeness":1.0,"reactions_with_gene":1,"genes":1,"norm_chokepoint":1.0,"druggable":"No","max_centrality":0.0,"norm_reactions":0.0175438596491228,"chokepoints":1},"properties":null,"score":0.0},{"term":"PWY-5853","name":"demethylmenaquinol-6 biosynthesis","count":1,"properties2":{"reactions":1,"completeness":1.0,"reactions_with_gene":1,"genes":1,"norm_chokepoint":1.0,"druggable":"No","max_centrality":0.00518673479575301,"norm_reactions":0.0175438596491228,"chokepoints":1},"properties":null,"score":0.0},{"term":"PWY-5852","name":"demethylmenaquinone-8 biosynthesis I","count":1,"properties2":{"reactions":1,"completeness":1.0,"reactions_with_gene":1,"genes":1,"norm_chokepoint":0.0,"druggable":"No","max_centrality":0.10518594572833,"norm_reactions":0.0175438596491228,"chokepoints":0},"properties":null,"score":0.0},{"term":"RIBITOLUTIL-PWY","name":"ribitol degradation","count":2,"properties2":{"reactions":2,"completeness":1.0,"reactions_with_gene":2,"genes":2,"norm_chokepoint":1.0,"druggable":"Yes","max_centrality":0.05415,"norm_reactions":0.0350877192982456,"chokepoints":2},"properties":null,"score":0.0},{"term":"ALADEG-PWY","name":"alanine degradation I","count":4,"properties2":{"reactions":2,"completeness":1.0,"reactions_with_gene":2,"genes":4,"norm_chokepoint":0.5,"druggable":"Yes","max_centrality":0.01151,"norm_reactions":0.0350877192982456,"chokepoints":1},"properties":null,"score":0.0},{"term":"BSUBPOLYAMSYN-PWY","name":"spermidine biosynthesis I","count":2,"properties2":{"reactions":2,"completeness":1.0,"reactions_with_gene":2,"genes":2,"norm_chokepoint":1.0,"druggable":"Yes","max_centrality":0.105978333676016,"norm_reactions":0.0350877192982456,"chokepoints":2},"properties":null,"score":0.0},{"term":"PWY-7686","name":"PWY-7686","count":1,"properties2":{"reactions":1,"completeness":1.0,"reactions_with_gene":1,"genes":1,"norm_chokepoint":0.0,"druggable":"No","max_centrality":0.11508,"norm_reactions":0.0175438596491228,"chokepoints":0},"properties":null,"score":0.0},{"term":"PWY0-1546","name":"muropeptide degradation","count":4,"properties2":{"reactions":4,"completeness":1.0,"reactions_with_gene":4,"genes":4,"norm_chokepoint":1.0,"druggable":"Yes","max_centrality":0.02145,"norm_reactions":0.0701754385964912,"chokepoints":4},"properties":null,"score":0.0},{"term":"GLUTSYNIII-PWY","name":"glutamate biosynthesis III","count":4,"properties2":{"reactions":1,"completeness":1.0,"reactions_with_gene":1,"genes":4,"norm_chokepoint":0.0,"druggable":"Yes","max_centrality":0.0,"norm_reactions":0.0175438596491228,"chokepoints":0},"properties":null,"score":0.0},{"term":"PWY0-1264","name":"biotin-carboxyl carrier protein assembly","count":5,"properties2":{"reactions":4,"completeness":0.75,"reactions_with_gene":3,"genes":5,"norm_chokepoint":1.0,"druggable":"Yes","max_centrality":0.31151,"norm_reactions":0.0701754385964912,"chokepoints":4},"properties":null,"score":0.0},{"term":"PWY0-1261","name":"anhydromuropeptides recycling","count":17,"properties2":{"reactions":12,"completeness":1.0,"reactions_with_gene":12,"genes":17,"norm_chokepoint":0.833333333333333,"druggable":"Yes","max_centrality":0.06008,"norm_reactions":0.210526315789474,"chokepoints":10},"properties":null,"score":0.0},{"term":"SAM-PWY","name":"S-adenosylmethionine biosynthesis","count":1,"properties2":{"reactions":1,"completeness":1.0,"reactions_with_gene":1,"genes":1,"norm_chokepoint":1.0,"druggable":"Yes","max_centrality":0.56331,"norm_reactions":0.0175438596491228,"chokepoints":1},"properties":null,"score":0.0},{"term":"PWY-6537","name":"4-aminobutyrate degradation II","count":5,"properties2":{"reactions":2,"completeness":1.0,"reactions_with_gene":2,"genes":5,"norm_chokepoint":0.5,"druggable":"Yes","max_centrality":0.0361703262387692,"norm_reactions":0.0350877192982456,"chokepoints":1},"properties":null,"score":0.0},{"term":"PWY-6536","name":"4-aminobutyrate degradation","count":2,"properties2":{"reactions":1,"completeness":1.0,"reactions_with_gene":1,"genes":2,"norm_chokepoint":1.0,"druggable":"Yes","max_centrality":0.0355691489575276,"norm_reactions":0.0175438596491228,"chokepoints":1},"properties":null,"score":0.0},{"term":"ARABCAT-PWY","name":"L-arabinose degradation I","count":4,"properties2":{"reactions":3,"completeness":1.0,"reactions_with_gene":3,"genes":4,"norm_chokepoint":1.0,"druggable":"Yes","max_centrality":0.03384,"norm_reactions":0.0526315789473684,"chokepoints":3},"properties":null,"score":0.0},{"term":"PWY0-1182","name":"trehalose degradation II (trehalase)","count":6,"properties2":{"reactions":5,"completeness":1.0,"reactions_with_gene":5,"genes":6,"norm_chokepoint":0.2,"druggable":"Yes","max_centrality":0.08233,"norm_reactions":0.087719298245614,"chokepoints":1},"properties":null,"score":0.0},{"term":"SERDEG-PWY","name":"L-serine degradation","count":1,"properties2":{"reactions":3,"completeness":0.333333333333333,"reactions_with_gene":1,"genes":1,"norm_chokepoint":0.666666666666667,"druggable":"No","max_centrality":0.0166044508633634,"norm_reactions":0.0526315789473684,"chokepoints":2},"properties":null,"score":0.0},{"term":"RIBOSYN2-PWY","name":"flavin biosynthesis I (bacteria and plants)","count":11,"properties2":{"reactions":9,"completeness":1.0,"reactions_with_gene":9,"genes":11,"norm_chokepoint":1.0,"druggable":"Yes","max_centrality":0.05184,"norm_reactions":0.157894736842105,"chokepoints":9},"properties":null,"score":0.0},{"term":"KDO-LIPASYN-PWY","name":"(KDO)2-lipid A biosynthesis I","count":3,"properties2":{"reactions":2,"completeness":1.0,"reactions_with_gene":2,"genes":3,"norm_chokepoint":1.0,"druggable":"No","max_centrality":0.0736102773829476,"norm_reactions":0.0350877192982456,"chokepoints":2},"properties":null,"score":0.0},{"term":"PWY-6071","name":"superpathway of phenylethylamine degradation","count":12,"properties2":{"reactions":11,"completeness":1.0,"reactions_with_gene":11,"genes":12,"norm_chokepoint":0.909090909090909,"druggable":"Yes","max_centrality":0.086,"norm_reactions":0.192982456140351,"chokepoints":10},"properties":null,"score":0.0},{"term":"PWY-6629","name":"superpathway of tryptophan biosynthesis","count":21,"properties2":{"reactions":14,"completeness":0.928571428571429,"reactions_with_gene":13,"genes":21,"norm_chokepoint":0.857142857142857,"druggable":"Yes","max_centrality":0.35353,"norm_reactions":0.245614035087719,"chokepoints":12},"properties":null,"score":0.0},{"term":"PWY-6628","name":"superpathway of phenylalanine biosynthesis","count":18,"properties2":{"reactions":11,"completeness":0.909090909090909,"reactions_with_gene":10,"genes":18,"norm_chokepoint":0.727272727272727,"druggable":"Yes","max_centrality":0.298476676010974,"norm_reactions":0.192982456140351,"chokepoints":8},"properties":null,"score":0.0},{"term":"ETOH-ACETYLCOA-ANA-PWY","name":"ethanol degradation I","count":5,"properties2":{"reactions":2,"completeness":1.0,"reactions_with_gene":2,"genes":5,"norm_chokepoint":0.0,"druggable":"Yes","max_centrality":0.32122,"norm_reactions":0.0350877192982456,"chokepoints":0},"properties":null,"score":0.0},{"term":"PWY-6620","name":"guanine and guanosine salvage","count":3,"properties2":{"reactions":2,"completeness":1.0,"reactions_with_gene":2,"genes":3,"norm_chokepoint":0.0,"druggable":"Yes","max_centrality":0.106984977148501,"norm_reactions":0.0350877192982456,"chokepoints":0},"properties":null,"score":0.0},{"term":"PWY-841","name":"purine nucleotides de novo biosynthesis II","count":34,"properties2":{"reactions":24,"completeness":0.958333333333333,"reactions_with_gene":23,"genes":34,"norm_chokepoint":0.5,"druggable":"Yes","max_centrality":0.34351,"norm_reactions":0.421052631578947,"chokepoints":12},"properties":null,"score":0.0},{"term":"PWY0-1356","name":"formate to dimethyl sulfoxide electron transfer","count":6,"properties2":{"reactions":2,"completeness":1.0,"reactions_with_gene":2,"genes":6,"norm_chokepoint":1.0,"druggable":"Yes","max_centrality":0.0358128816540709,"norm_reactions":0.0350877192982456,"chokepoints":2},"properties":null,"score":0.0},{"term":"PWY0-301","name":"L-ascorbate degradation I (bacterial, anaerobic)","count":5,"properties2":{"reactions":4,"completeness":1.0,"reactions_with_gene":4,"genes":5,"norm_chokepoint":1.0,"druggable":"Yes","max_centrality":0.03384,"norm_reactions":0.0701754385964912,"chokepoints":4},"properties":null,"score":0.0},{"term":"PWY-2361","name":"3-oxoadipate degradation","count":2,"properties2":{"reactions":2,"completeness":1.0,"reactions_with_gene":2,"genes":2,"norm_chokepoint":0.5,"druggable":"Yes","max_centrality":0.157138838258809,"norm_reactions":0.0350877192982456,"chokepoints":1},"properties":null,"score":0.0},{"term":"PWY-5886","name":"4-hydroxyphenylpyruvate biosynthesis","count":2,"properties2":{"reactions":1,"completeness":1.0,"reactions_with_gene":1,"genes":2,"norm_chokepoint":0.0,"druggable":"Yes","max_centrality":0.0385267338878579,"norm_reactions":0.0175438596491228,"chokepoints":0},"properties":null,"score":0.0},{"term":"PWY-5921","name":"L-glutamine biosynthesis II (tRNA-dependent)","count":2,"properties2":{"reactions":2,"completeness":1.0,"reactions_with_gene":2,"genes":2,"norm_chokepoint":1.0,"druggable":"Yes","max_centrality":0.00909,"norm_reactions":0.0350877192982456,"chokepoints":2},"properties":null,"score":0.0},{"term":"PWY-2161","name":"folate polyglutamylation","count":2,"properties2":{"reactions":2,"completeness":1.0,"reactions_with_gene":2,"genes":2,"norm_chokepoint":0.0,"druggable":"Yes","max_centrality":0.632073787311858,"norm_reactions":0.0350877192982456,"chokepoints":0},"properties":null,"score":0.0},{"term":"BETSYN-PWY","name":"glycine betaine biosynthesis I (Gram-negative bacteria)","count":2,"properties2":{"reactions":2,"completeness":1.0,"reactions_with_gene":2,"genes":2,"norm_chokepoint":1.0,"druggable":"Yes","max_centrality":2.0E-5,"norm_reactions":0.0350877192982456,"chokepoints":2},"properties":null,"score":0.0},{"term":"PYRIDNUCSYN-PWY","name":"NAD biosynthesis I (from aspartate)","count":6,"properties2":{"reactions":6,"completeness":1.0,"reactions_with_gene":6,"genes":6,"norm_chokepoint":0.5,"druggable":"Yes","max_centrality":0.07011,"norm_reactions":0.105263157894737,"chokepoints":3},"properties":null,"score":0.0},{"term":"PEPTIDOGLYCANSYN-PWY","name":"peptidoglycan biosynthesis I (meso-diaminopimelate containing)","count":10,"properties2":{"reactions":10,"completeness":1.0,"reactions_with_gene":10,"genes":10,"norm_chokepoint":0.9,"druggable":"Yes","max_centrality":0.07715,"norm_reactions":0.175438596491228,"chokepoints":9},"properties":null,"score":0.0},{"term":"PWY-7663","name":"PWY-7663","count":6,"properties2":{"reactions":4,"completeness":1.0,"reactions_with_gene":4,"genes":6,"norm_chokepoint":1.0,"druggable":"Yes","max_centrality":0.02155,"norm_reactions":0.0701754385964912,"chokepoints":4},"properties":null,"score":0.0},{"term":"PWY-5194","name":"siroheme biosynthesis","count":12,"properties2":{"reactions":4,"completeness":1.0,"reactions_with_gene":4,"genes":12,"norm_chokepoint":1.0,"druggable":"Yes","max_centrality":0.021,"norm_reactions":0.0701754385964912,"chokepoints":4},"properties":null,"score":0.0},{"term":"PPGPPMET-PWY","name":"ppGpp biosynthesis","count":8,"properties2":{"reactions":6,"completeness":1.0,"reactions_with_gene":6,"genes":8,"norm_chokepoint":0.333333333333333,"druggable":"Yes","max_centrality":0.0104180280000912,"norm_reactions":0.105263157894737,"chokepoints":2},"properties":null,"score":0.0},{"term":"PWY-5755","name":"4-hydroxybenzoate biosynthesis II (bacteria and fungi)","count":1,"properties2":{"reactions":1,"completeness":1.0,"reactions_with_gene":1,"genes":1,"norm_chokepoint":1.0,"druggable":"Yes","max_centrality":0.0594687158333972,"norm_reactions":0.0175438596491228,"chokepoints":1},"properties":null,"score":0.0},{"term":"PWY-7228","name":"superpathway of guanosine nucleotides de novo biosynthesis I","count":17,"properties2":{"reactions":8,"completeness":1.0,"reactions_with_gene":8,"genes":17,"norm_chokepoint":0.125,"druggable":"Yes","max_centrality":0.26904,"norm_reactions":0.140350877192982,"chokepoints":1},"properties":null,"score":0.0},{"term":"PWY-7229","name":"superpathway of adenosine nucleotides de novo biosynthesis I","count":6,"properties2":{"reactions":6,"completeness":0.833333333333333,"reactions_with_gene":5,"genes":6,"norm_chokepoint":0.5,"druggable":"Yes","max_centrality":0.34351,"norm_reactions":0.105263157894737,"chokepoints":3},"properties":null,"score":0.0},{"term":"RIBOKIN-PWY","name":"ribose degradation","count":3,"properties2":{"reactions":3,"completeness":0.666666666666667,"reactions_with_gene":2,"genes":3,"norm_chokepoint":0.333333333333333,"druggable":"Yes","max_centrality":2.3E-4,"norm_reactions":0.0526315789473684,"chokepoints":1},"properties":null,"score":0.0},{"term":"PWY-7221","name":"guanosine ribonucleotides de novo biosynthesis","count":14,"properties2":{"reactions":6,"completeness":1.0,"reactions_with_gene":6,"genes":14,"norm_chokepoint":0.0,"druggable":"Yes","max_centrality":0.26904,"norm_reactions":0.105263157894737,"chokepoints":0},"properties":null,"score":0.0},{"term":"PWY-7222","name":"guanosine deoxyribonucleotides de novo biosynthesis II","count":6,"properties2":{"reactions":4,"completeness":1.0,"reactions_with_gene":4,"genes":6,"norm_chokepoint":0.25,"druggable":"Yes","max_centrality":0.136808829916637,"norm_reactions":0.0701754385964912,"chokepoints":1},"properties":null,"score":0.0},{"term":"PWY-7226","name":"guanosine deoxyribonucleotides de novo biosynthesis I","count":3,"properties2":{"reactions":2,"completeness":1.0,"reactions_with_gene":2,"genes":3,"norm_chokepoint":0.5,"druggable":"Yes","max_centrality":0.136808829916637,"norm_reactions":0.0350877192982456,"chokepoints":1},"properties":null,"score":0.0},{"term":"PWY-6282","name":"palmitoleate biosynthesis I","count":12,"properties2":{"reactions":9,"completeness":0.888888888888889,"reactions_with_gene":8,"genes":12,"norm_chokepoint":1.0,"druggable":"Yes","max_centrality":0.02905,"norm_reactions":0.157894736842105,"chokepoints":9},"properties":null,"score":0.0},{"term":"PWY-6952","name":"glycerophosphodiester degradation","count":4,"properties2":{"reactions":1,"completeness":1.0,"reactions_with_gene":1,"genes":4,"norm_chokepoint":0.0,"druggable":"Yes","max_centrality":1.50295073018423E-4,"norm_reactions":0.0175438596491228,"chokepoints":0},"properties":null,"score":0.0},{"term":"PWY-5686","name":"uridine-5'-phosphate biosynthesis","count":25,"properties2":{"reactions":11,"completeness":1.0,"reactions_with_gene":11,"genes":25,"norm_chokepoint":0.545454545454545,"druggable":"Yes","max_centrality":0.12857,"norm_reactions":0.192982456140351,"chokepoints":6},"properties":null,"score":0.0},{"term":"TYRFUMCAT-PWY","name":"tyrosine degradation I","count":4,"properties2":{"reactions":5,"completeness":0.6,"reactions_with_gene":3,"genes":4,"norm_chokepoint":0.8,"druggable":"Yes","max_centrality":0.0385267338878579,"norm_reactions":0.087719298245614,"chokepoints":4},"properties":null,"score":0.0},{"term":"THISYN-PWY","name":"thiamin biosynthesis I","count":11,"properties2":{"reactions":11,"completeness":1.0,"reactions_with_gene":11,"genes":11,"norm_chokepoint":0.818181818181818,"druggable":"Yes","max_centrality":0.10271,"norm_reactions":0.192982456140351,"chokepoints":9},"properties":null,"score":0.0},{"term":"PWY0-1221","name":"putrescine degradation II","count":5,"properties2":{"reactions":5,"completeness":1.0,"reactions_with_gene":5,"genes":5,"norm_chokepoint":0.6,"druggable":"Yes","max_centrality":0.03098,"norm_reactions":0.087719298245614,"chokepoints":3},"properties":null,"score":0.0},{"term":"GLUCARGALACTSUPER-PWY","name":"superpathway of D-glucarate and D-galactarate degradation","count":6,"properties2":{"reactions":5,"completeness":1.0,"reactions_with_gene":5,"genes":6,"norm_chokepoint":0.8,"druggable":"Yes","max_centrality":0.0230810765312747,"norm_reactions":0.087719298245614,"chokepoints":4},"properties":null,"score":0.0},{"term":"GLUTAMINDEG-PWY","name":"glutamine degradation I","count":9,"properties2":{"reactions":1,"completeness":1.0,"reactions_with_gene":1,"genes":9,"norm_chokepoint":0.0,"druggable":"Yes","max_centrality":0.00234,"norm_reactions":0.0175438596491228,"chokepoints":0},"properties":null,"score":0.0},{"term":"GLYCOLYSIS-E-D","name":"superpathway of glycolysis and Entner-Doudoroff","count":38,"properties2":{"reactions":20,"completeness":1.0,"reactions_with_gene":20,"genes":38,"norm_chokepoint":0.2,"druggable":"Yes","max_centrality":0.319,"norm_reactions":0.350877192982456,"chokepoints":4},"properties":null,"score":0.0},{"term":"PWY-5861","name":"superpathway of demethylmenaquinone-8 biosynthesis","count":12,"properties2":{"reactions":9,"completeness":1.0,"reactions_with_gene":9,"genes":12,"norm_chokepoint":0.777777777777778,"druggable":"Yes","max_centrality":0.116477620429252,"norm_reactions":0.157894736842105,"chokepoints":7},"properties":null,"score":0.0},{"term":"PROUT-PWY","name":"proline degradation","count":2,"properties2":{"reactions":3,"completeness":0.666666666666667,"reactions_with_gene":2,"genes":2,"norm_chokepoint":0.333333333333333,"druggable":"Yes","max_centrality":0.01682,"norm_reactions":0.0526315789473684,"chokepoints":1},"properties":null,"score":0.0},{"term":"GALACT-GLUCUROCAT-PWY","name":"superpathway of hexuronide and hexuronate degradation","count":11,"properties2":{"reactions":10,"completeness":0.8,"reactions_with_gene":8,"genes":11,"norm_chokepoint":0.9,"druggable":"Yes","max_centrality":0.15854,"norm_reactions":0.175438596491228,"chokepoints":9},"properties":null,"score":0.0},{"term":"PWY0-1535","name":"D-serine degradation","count":1,"properties2":{"reactions":3,"completeness":0.333333333333333,"reactions_with_gene":1,"genes":1,"norm_chokepoint":0.666666666666667,"druggable":"Yes","max_centrality":0.00518673479575301,"norm_reactions":0.0526315789473684,"chokepoints":2},"properties":null,"score":0.0},{"term":"GLUCONEO-PWY","name":"gluconeogenesis I","count":23,"properties2":{"reactions":14,"completeness":1.0,"reactions_with_gene":14,"genes":23,"norm_chokepoint":0.0,"druggable":"Yes","max_centrality":0.319,"norm_reactions":0.245614035087719,"chokepoints":0},"properties":null,"score":0.0},{"term":"ORNDEG-PWY","name":"superpathway of ornithine degradation","count":8,"properties2":{"reactions":8,"completeness":1.0,"reactions_with_gene":8,"genes":8,"norm_chokepoint":0.5,"druggable":"Yes","max_centrality":0.142336268263367,"norm_reactions":0.140350877192982,"chokepoints":4},"properties":null,"score":0.0},{"term":"SORBDEG-PWY","name":"D-sorbitol degradation II","count":1,"properties2":{"reactions":2,"completeness":0.5,"reactions_with_gene":1,"genes":1,"norm_chokepoint":1.0,"druggable":"Yes","max_centrality":0.00466847592327569,"norm_reactions":0.0350877192982456,"chokepoints":2},"properties":null,"score":0.0},{"term":"GLUTSYN-PWY","name":"glutamate biosynthesis I","count":15,"properties2":{"reactions":3,"completeness":1.0,"reactions_with_gene":3,"genes":15,"norm_chokepoint":0.0,"druggable":"Yes","max_centrality":0.00234,"norm_reactions":0.0526315789473684,"chokepoints":0},"properties":null,"score":0.0},{"term":"BRANCHED-CHAIN-AA-SYN-PWY","name":"superpathway of leucine, valine, and isoleucine biosynthesis","count":33,"properties2":{"reactions":17,"completeness":0.823529411764706,"reactions_with_gene":14,"genes":33,"norm_chokepoint":0.941176470588235,"druggable":"Yes","max_centrality":0.05747,"norm_reactions":0.298245614035088,"chokepoints":16},"properties":null,"score":0.0},{"term":"PWY-6543","name":"4-aminobenzoate biosynthesis","count":3,"properties2":{"reactions":2,"completeness":1.0,"reactions_with_gene":2,"genes":3,"norm_chokepoint":1.0,"druggable":"Yes","max_centrality":0.02713,"norm_reactions":0.0350877192982456,"chokepoints":2},"properties":null,"score":0.0},{"term":"GLUCUROCAT-PWY","name":"superpathway of β-D-glucuronide and D-glucuronate degradation","count":8,"properties2":{"reactions":7,"completeness":0.714285714285714,"reactions_with_gene":5,"genes":8,"norm_chokepoint":0.857142857142857,"druggable":"Yes","max_centrality":0.15854,"norm_reactions":0.12280701754386,"chokepoints":6},"properties":null,"score":0.0},{"term":"PWY0-1319","name":"CDP-diacylglycerol biosynthesis II","count":5,"properties2":{"reactions":4,"completeness":1.0,"reactions_with_gene":4,"genes":5,"norm_chokepoint":0.75,"druggable":"No","max_centrality":0.139305043533121,"norm_reactions":0.0701754385964912,"chokepoints":3},"properties":null,"score":0.0},{"term":"PWY0-1544","name":"proline to cytochrome bo oxidase electron transfer","count":4,"properties2":{"reactions":2,"completeness":1.0,"reactions_with_gene":2,"genes":4,"norm_chokepoint":0.0,"druggable":"Yes","max_centrality":0.0306318634107291,"norm_reactions":0.0350877192982456,"chokepoints":0},"properties":null,"score":0.0},{"term":"PWY-621","name":"sucrose degradation III","count":13,"properties2":{"reactions":9,"completeness":1.0,"reactions_with_gene":9,"genes":13,"norm_chokepoint":0.111111111111111,"druggable":"Yes","max_centrality":0.319,"norm_reactions":0.157894736842105,"chokepoints":1},"properties":null,"score":0.0},{"term":"PWY-5964","name":"guanylyl molybdenum cofactor biosynthesis","count":2,"properties2":{"reactions":1,"completeness":1.0,"reactions_with_gene":1,"genes":2,"norm_chokepoint":1.0,"druggable":"Yes","max_centrality":0.0,"norm_reactions":0.0175438596491228,"chokepoints":1},"properties":null,"score":0.0},{"term":"GLUTDEG-PWY","name":"glutamate degradation II","count":2,"properties2":{"reactions":2,"completeness":1.0,"reactions_with_gene":2,"genes":2,"norm_chokepoint":0.0,"druggable":"Yes","max_centrality":0.03642,"norm_reactions":0.0350877192982456,"chokepoints":0},"properties":null,"score":0.0},{"term":"SER-GLYSYN-PWY","name":"superpathway of serine and glycine biosynthesis I","count":4,"properties2":{"reactions":4,"completeness":1.0,"reactions_with_gene":4,"genes":4,"norm_chokepoint":0.75,"druggable":"Yes","max_centrality":0.632073787311858,"norm_reactions":0.0701754385964912,"chokepoints":3},"properties":null,"score":0.0},{"term":"KDOSYN-PWY","name":"KDO transfer to lipid IVA I","count":2,"properties2":{"reactions":2,"completeness":1.0,"reactions_with_gene":2,"genes":2,"norm_chokepoint":1.0,"druggable":"Yes","max_centrality":0.05239,"norm_reactions":0.0350877192982456,"chokepoints":2},"properties":null,"score":0.0},{"term":"PWY-7545","name":"pyruvate to cytochrome bd terminal oxidase electron transfer","count":6,"properties2":{"reactions":2,"completeness":1.0,"reactions_with_gene":2,"genes":6,"norm_chokepoint":0.5,"druggable":"Yes","max_centrality":0.0306318634107291,"norm_reactions":0.0350877192982456,"chokepoints":1},"properties":null,"score":0.0},{"term":"PWY-7544","name":"pyruvate to cytochrome bo oxidase electron transfer","count":4,"properties2":{"reactions":2,"completeness":1.0,"reactions_with_gene":2,"genes":4,"norm_chokepoint":0.5,"druggable":"Yes","max_centrality":0.0306318634107291,"norm_reactions":0.0350877192982456,"chokepoints":1},"properties":null,"score":0.0},{"term":"PWY0-1021","name":"alanine biosynthesis III","count":1,"properties2":{"reactions":1,"completeness":1.0,"reactions_with_gene":1,"genes":1,"norm_chokepoint":1.0,"druggable":"Yes","max_centrality":0.10271,"norm_reactions":0.0175438596491228,"chokepoints":1},"properties":null,"score":0.0},{"term":"PWY-7622","name":"UDP-galactofuranose biosynthesis","count":3,"properties2":{"reactions":2,"completeness":1.0,"reactions_with_gene":2,"genes":3,"norm_chokepoint":0.5,"druggable":"Yes","max_centrality":0.0077,"norm_reactions":0.0350877192982456,"chokepoints":1},"properties":null,"score":0.0},{"term":"PWY0-501","name":"lipoate biosynthesis and incorporation I","count":2,"properties2":{"reactions":2,"completeness":1.0,"reactions_with_gene":2,"genes":2,"norm_chokepoint":0.5,"druggable":"Yes","max_centrality":0.202564084485117,"norm_reactions":0.0350877192982456,"chokepoints":1},"properties":null,"score":0.0},{"term":"NONOXIPENT-PWY","name":"pentose phosphate pathway (non-oxidative branch)","count":20,"properties2":{"reactions":5,"completeness":1.0,"reactions_with_gene":5,"genes":20,"norm_chokepoint":0.2,"druggable":"Yes","max_centrality":0.172972369877888,"norm_reactions":0.087719298245614,"chokepoints":1},"properties":null,"score":0.0}],"kegg":null,"druggabilityParams":[{"name":"has_structure","description":"Protein has a 3D structure","type":"value","target":"structure","uploader":"demo","options":["true","false"],"org_name":null,"defaultGroupOperation":"avg","defaultOperation":"equal","defaultValue":"true"},{"name":"structure_type","description":"Experimentally obtained or modelled","type":"value","target":"structure","uploader":"demo","options":["experimental","model"],"org_name":null,"defaultGroupOperation":"avg","defaultOperation":"equal","defaultValue":"experimental"},{"name":"druggability","description":"Druggability score from the most druggable pocket. Druggable: druggability > 0.5 / Highly Druggable druggability > 0.7. (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4014675/)","type":"number","target":"structure","uploader":"demo","options":[],"org_name":null,"defaultGroupOperation":"avg","defaultOperation":">","defaultValue":"0.5"},{"name":"hydrophobicity","description":"Hydrophobicity of the most druggable pocket","type":"number","target":"structure","uploader":"demo","options":[],"org_name":null,"defaultGroupOperation":"avg","defaultOperation":">","defaultValue":null},{"name":"volume","description":"Volume in cubic Å of the most druggable pocket","type":"number","target":"structure","uploader":"demo","options":[],"org_name":null,"defaultGroupOperation":"avg","defaultOperation":">","defaultValue":null},{"name":"free_tyr","description":"One of the protein structures has a tyr without atoms surrounding the oxygen of the OH group (more than 3 cubic Å )","type":"value","target":"structure","uploader":"demo","options":["true","false"],"org_name":null,"defaultGroupOperation":null,"defaultOperation":null,"defaultValue":null},{"name":"tyr","description":"One of the protein structures has a tyr residue","type":"value","target":"structure","uploader":"demo","options":["true","false"],"org_name":null,"defaultGroupOperation":null,"defaultOperation":null,"defaultValue":null},{"name":"free_cys","description":"One of the protein structures has a cys without atoms surrounding the S atom of the SH group (more than 3 Å )","type":"value","target":"structure","uploader":"demo","options":["true","false"],"org_name":null,"defaultGroupOperation":null,"defaultOperation":null,"defaultValue":null},{"name":"cys","description":"One of the protein structures has a cys residue","type":"value","target":"structure","uploader":"demo","options":["true","false"],"org_name":null,"defaultGroupOperation":null,"defaultOperation":null,"defaultValue":null},{"name":"csa","description":"One of the protein structures has at least one residue reported in the Catalitic Site Atlas database","type":"value","target":"structure","uploader":"demo","options":["true","false"],"org_name":null,"defaultGroupOperation":null,"defaultOperation":null,"defaultValue":null},{"name":"domain_extended","description":"One of the protein cristals has a pfam domain with residues near a drug or cofactor","type":"value","target":"structure","uploader":"demo","options":["true","false"],"org_name":null,"defaultGroupOperation":null,"defaultOperation":null,"defaultValue":null},{"name":"pocket_with_free_tyr","description":"One of the protein structures has a tyr inside a pocket without atoms surrounding the oxygen of the OH group (more than 3 cubic Å )","type":"value","target":"pocket","uploader":"demo","options":["true","false"],"org_name":null,"defaultGroupOperation":null,"defaultOperation":null,"defaultValue":null},{"name":"pocket_with_tyr","description":"One of the protein structures has a tyr inside a pocket","type":"value","target":"pocket","uploader":"demo","options":["true","false"],"org_name":null,"defaultGroupOperation":null,"defaultOperation":null,"defaultValue":null},{"name":"pocket_with_free_cys","description":"One of the protein structures has a cys inside a pocket without atoms surrounding the S atom of the SH group (more than 3 Å )","type":"value","target":"pocket","uploader":"demo","options":["true","false"],"org_name":null,"defaultGroupOperation":null,"defaultOperation":null,"defaultValue":null},{"name":"pocket_with_cys","description":"One of the protein structures has a cys residue inside a pocket","type":"value","target":"pocket","uploader":"demo","options":["true","false"],"org_name":null,"defaultGroupOperation":null,"defaultOperation":null,"defaultValue":null},{"name":"pocket_with_csa","description":"One of the protein structures has at least one residue inside a pocket reported in the Catalitic Site Atlas database","type":"value","target":"pocket","uploader":"demo","options":["true","false"],"org_name":null,"defaultGroupOperation":null,"defaultOperation":null,"defaultValue":null},{"name":"pocket_with_domain_extended","description":"One of the protein crystal has a pfam domain with residues inside a pocket near a drug or cofactor","type":"value","target":"pocket","uploader":"demo","options":["true","false"],"org_name":null,"defaultGroupOperation":null,"defaultOperation":null,"defaultValue":null},{"name":"pocket_with_pfam_imp_residue","description":"One of the protein structures, has at least one residue, inside a pocket and a pfam domain, in contact (less than 3 Å ) with a drug or cofactor","type":"value","target":"pocket","uploader":"demo","options":["true","false"],"org_name":null,"defaultGroupOperation":null,"defaultOperation":null,"defaultValue":null},{"name":"drug_binding","description":"One of the protein structures has at least one residue in contact with a drug (less than 3 Å )","type":"value","target":"structure","uploader":"demo","options":["true","false"],"org_name":null,"defaultGroupOperation":"avg","defaultOperation":"equal","defaultValue":"true"},{"name":"pocket_with_drug_binding","description":"One of the protein structures has at least one pocket residue in contact with a drug (less than 3 Å )","type":"value","target":"pocket","uploader":"demo","options":["true","false"],"org_name":null,"defaultGroupOperation":"avg","defaultOperation":"equal","defaultValue":"true"},{"name":"lipid_binding","description":"One of the protein structures has at least one residue in contact with a lipid (less than 3 Å )","type":"value","target":"structure","uploader":"demo","options":["true","false"],"org_name":null,"defaultGroupOperation":"avg","defaultOperation":"equal","defaultValue":"true"},{"name":"pocket_with_lipid_binding","description":"One of the protein structures has at least one pocket residue in contact with a lipid (less than 3 Å )","type":"value","target":"pocket","uploader":"demo","options":["true","false"],"org_name":null,"defaultGroupOperation":"avg","defaultOperation":"equal","defaultValue":"true"},{"name":"metal_binding","description":"One of the protein structures has at least one residue in contact with a metal (less than 3 Å )","type":"value","target":"structure","uploader":"demo","options":["true","false"],"org_name":null,"defaultGroupOperation":"avg","defaultOperation":"equal","defaultValue":"true"},{"name":"pocket_with_metal_binding","description":"One of the protein structures has at least one pocket residue in contact with a metal (less than 3 Å ) ","type":"value","target":"pocket","uploader":"demo","options":["true","false"],"org_name":null,"defaultGroupOperation":"avg","defaultOperation":"equal","defaultValue":"true"},{"name":"nucleotide_binding","description":"One of the protein structures has at least one residue in contact with a nucleotide (less than 3 Å ) ","type":"value","target":"structure","uploader":"demo","options":["true","false"],"org_name":null,"defaultGroupOperation":"avg","defaultOperation":"equal","defaultValue":"true"},{"name":"pocket_with_nucleotide_binding","description":"One of the protein structures has at least one pocket residue in contact with a nucleotide (less than 3 Å ) ","type":"value","target":"pocket","uploader":"demo","options":["true","false"],"org_name":null,"defaultGroupOperation":"avg","defaultOperation":"equal","defaultValue":"true"},{"name":"sugar_binding","description":"One of the protein structures has at least one residue in contact with a sugar (less than 3 Å )","type":"value","target":"structure","uploader":"demo","options":["true","false"],"org_name":null,"defaultGroupOperation":"avg","defaultOperation":"equal","defaultValue":"true"},{"name":"pocket_with_sugar_binding","description":"One of the protein structures has at least one pocket residue in contact with asugar (less than 3 Å)","type":"value","target":"pocket","uploader":"demo","options":["true","false"],"org_name":null,"defaultGroupOperation":"avg","defaultOperation":"equal","defaultValue":"true"},{"name":"centrality","description":"Shortest-path betweenness centrality (normalized) for reactions. \n In the used graph the nodes are the reactions and the edges the metabolites conecting them.\n When centrality >= 0.1 the reaction is considered highly central\n ","type":"number","target":"pathways","uploader":"demo","options":[],"org_name":null,"defaultGroupOperation":"max","defaultOperation":">","defaultValue":"0.1"},{"name":"chokepoint","description":"The protein catalyzes a chokepoint reaction ","type":"value","target":"pathways","uploader":"demo","options":["true","false"],"org_name":null,"defaultGroupOperation":"avg","defaultOperation":"equal","defaultValue":"true"},{"name":"chokepoint_type","description":"Chokepoint reaction type (consume, production or double)","type":"value","target":"pathways","uploader":"demo","options":["consuming","double","production"],"org_name":null,"defaultGroupOperation":"avg","defaultOperation":"equal","defaultValue":"true"},{"name":"reactions","description":"Number of reactions in the pathway","type":"number","target":"pathway","uploader":"demo","options":[],"org_name":null,"defaultGroupOperation":"avg","defaultOperation":">","defaultValue":"0"},{"name":"norm_reactions","description":"Number of reactions normalized by the highest pathway (with more reactions)","type":"number","target":"pathway","uploader":"demo","options":[],"org_name":null,"defaultGroupOperation":"avg","defaultOperation":">","defaultValue":"0"},{"name":"reactions_with_gene","description":"Number of reactions in the pathway with at least one known protein that catalize them","type":"number","target":"pathway","uploader":"demo","options":[],"org_name":null,"defaultGroupOperation":"avg","defaultOperation":">","defaultValue":"0"},{"name":"completeness","description":"Proportion of reactions in the pathway with at least one known protein that catalize them","type":"number","target":"pathway","uploader":"demo","options":[],"org_name":null,"defaultGroupOperation":"max","defaultOperation":">","defaultValue":"0.8"},{"name":"chokepoints","description":"Number of chokepoints reactions in the pathway","type":"number","target":"pathway","uploader":"demo","options":[],"org_name":null,"defaultGroupOperation":"avg","defaultOperation":">","defaultValue":"0"},{"name":"norm_chokepoint","description":"Chokepoint reactions/reactions in pathway ratio","type":"number","target":"pathway","uploader":"demo","options":[],"org_name":null,"defaultGroupOperation":"avg","defaultOperation":">","defaultValue":"0"},{"name":"druggable","description":"The pathway has at least one druggable protein","type":"value","target":"pathway","uploader":"demo","options":["Yes","No"],"org_name":null,"defaultGroupOperation":"avg","defaultOperation":"equal","defaultValue":"Yes"},{"name":"max_centrality","description":"Maximum betweenes centrality of all the reactions in the pathway, normalized by the reaction with max betweenes centrality in the whole graph","type":"number","target":"pathway","uploader":"demo","options":[],"org_name":null,"defaultGroupOperation":"avg","defaultOperation":">","defaultValue":"0.2"},{"name":"hit_in_deg","description":"Has a hit in Database of Essential Genes","type":"value","target":"protein","uploader":"demo","options":["No","Yes"],"org_name":null,"defaultGroupOperation":"avg","defaultOperation":"equal","defaultValue":"Yes"},{"name":"essential_in_mgh78578","description":"Hits with an essential gene of Klebsiella pneumoniae MGH78578","type":"value","target":"protein","uploader":"demo","options":["No","Yes"],"org_name":null,"defaultGroupOperation":"avg","defaultOperation":"equal","defaultValue":"Yes"},{"name":"conserved_pathogen","description":"Blast hit count in different pathogen Klebsiella subspecies","type":"number","target":"protein","uploader":"demo","options":[],"org_name":null,"defaultGroupOperation":"avg","defaultOperation":">","defaultValue":"35.49"},{"name":"conserved_pathogen_bbh","description":"BBH count in different pathogen Klebsiella subspecies","type":"number","target":"protein","uploader":"demo","options":[],"org_name":null,"defaultGroupOperation":"avg","defaultOperation":">","defaultValue":"35.49"},{"name":"conserved_no_pathogen","description":"Hit count in different non pathogen Klebsiella subspecies","type":"number","target":"protein","uploader":"demo","options":[],"org_name":null,"defaultGroupOperation":"avg","defaultOperation":">","defaultValue":"2.61"},{"name":"overexpressed_in_polymyxin","description":"Overexpressed in polymyxin B resistance induction (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5088521/)","type":"value","target":"protein","uploader":"demo","options":["NO","YES"],"org_name":null,"defaultGroupOperation":"avg","defaultOperation":"equal","defaultValue":"YES"},{"name":"overexpressed_in_polymixin_all_conditions","description":"Overexpressed in presence of Polymyxin in different conditions (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5088521/)","type":"value","target":"protein","uploader":"demo","options":["NO","YES"],"org_name":null,"defaultGroupOperation":"avg","defaultOperation":"equal","defaultValue":"YES"},{"name":"conserved_pathogen_norm","description":"Hit count in different pathogenic Kp strains divided by the total number of compared bacteria (38 pathogenic Kp).","type":"number","target":"protein","uploader":"demo","options":[],"org_name":null,"defaultGroupOperation":"avg","defaultOperation":">","defaultValue":"0.91"},{"name":"conserved_pathogen_bbh_norm","description":"Hit count in different pathogenic Kp strains divided by the total number of compared bacteria (38 pathogenic Kp).","type":"number","target":"protein","uploader":"demo","options":[],"org_name":null,"defaultGroupOperation":"avg","defaultOperation":">","defaultValue":"0.91"},{"name":"conserved_no_pathogen_norm","description":"Hit count in different non pathogenic Kp strains divided by the total number of compared bacteria (4 non pathogenic Kp).","type":"number","target":"protein","uploader":"demo","options":[],"org_name":null,"defaultGroupOperation":"avg","defaultOperation":">","defaultValue":"0.65"},{"name":"gut_microbiome","description":"Number of gut microbiome organisms that have at least one hit with the Kp13 protein (blast: identity > 40% evalue 1e-5)","type":"number","target":"protein","uploader":"demo","options":[],"org_name":null,"defaultGroupOperation":null,"defaultOperation":null,"defaultValue":null},{"name":"gut_microbiome_norm","description":"gut_microbiome normalized by the total number of compared bacteria (226)","type":"number","target":"protein","uploader":"demo","options":[],"org_name":null,"defaultGroupOperation":null,"defaultOperation":null,"defaultValue":null},{"name":"human_offtarget","description":"This score reflects the results of a blastp search of the pathogen protein in the human proteome database (ncbi accession GCF_000001405.36) with the scale 1 - max(alignment identity), so when a protein has no hit in the human proteome, the value is 1, and if it has 2 hits, one with an identity of 0.4 and other with 0.6, the score is 0.4 (human_offtarget = 1 - 0.6, uses the max identity).","type":"number","target":"protein","uploader":"demo","options":[],"org_name":null,"defaultGroupOperation":"max","defaultOperation":">","defaultValue":"0.6"},{"name":"essentiality","description":"Critical for the organism survival (https://www.ncbi.nlm.nih.gov/pubmed/28760848)","type":"value","target":"protein","uploader":"demo","options":["yes","no"],"org_name":null,"defaultGroupOperation":null,"defaultOperation":null,"defaultValue":null},{"name":"overexpression_in_carbapenem","description":"","type":"value","target":"protein","uploader":"demo","options":["Yes","No"],"org_name":null,"defaultGroupOperation":null,"defaultOperation":null,"defaultValue":null}],"uploads":[{"uploader":"eze","timestamp":1474741515424,"errors":["585 KP01079 does not exists in Kp13","587 KP01083 does not exists in Kp13","678 KP01247 does not exists in Kp13","883 KP01728 does not exists in Kp13","1598 KP03061 does not exists in Kp13","1843 KP03526 does not exists in Kp13","2649 KP05119 does not exists in Kp13","2768 KP05321 does not exists in Kp13","3042 KP31595 does not exists in Kp13","3160 KP31992 does not exists in Kp13","3199 KP32179 does not exists in Kp13","3225 KP32375 does not exists in Kp13","3230 gene field is empty"],"properties":["hit_in_deg","homolog_to_mgh78578","total_pathogen","total_no_pathogen","overexpressed_in_polymyxin","overexpressed_in_polymixin_all_conditions"],"formatedTimestamp":"24-9-2016 06:25:15"},{"uploader":"eze","timestamp":1474747677846,"errors":["585 KP01079 does not exists in Kp13","587 KP01083 does not exists in Kp13","678 KP01247 does not exists in Kp13","883 KP01728 does not exists in Kp13","1598 KP03061 does not exists in Kp13","1843 KP03526 does not exists in Kp13","2649 KP05119 does not exists in Kp13","2768 KP05321 does not exists in Kp13","3042 KP31595 does not exists in Kp13","3160 KP31992 does not exists in Kp13","3199 KP32179 does not exists in Kp13","3225 KP32375 does not exists in Kp13"],"properties":["hit_in_deg","homolog_to_mgh78578","total_pathogen","total_no_pathogen","overexpressed_in_polymyxin","overexpressed_in_polymixin_all_conditions"],"formatedTimestamp":"24-9-2016 08:07:57"},{"uploader":"eze","timestamp":1474748680027,"errors":["585 KP01079 does not exists in Kp13","587 KP01083 does not exists in Kp13","678 KP01247 does not exists in Kp13","883 KP01728 does not exists in Kp13","1598 KP03061 does not exists in Kp13","1843 KP03526 does not exists in Kp13","2649 KP05119 does not exists in Kp13","2768 KP05321 does not exists in Kp13","3042 KP31595 does not exists in Kp13","3160 KP31992 does not exists in Kp13","3199 KP32179 does not exists in Kp13","3225 KP32375 does not exists in Kp13"],"properties":["hit_in_deg","homolog_to_mgh78578","total_pathogen","total_no_pathogen","overexpressed_in_polymyxin","overexpressed_in_polymixin_all_conditions"],"formatedTimestamp":"24-9-2016 08:24:40"},{"uploader":"eze","timestamp":1475852699315,"errors":["585 KP01079 does not exists in Kp13","587 KP01083 does not exists in Kp13","678 KP01247 does not exists in Kp13","883 KP01728 does not exists in Kp13","1598 KP03061 does not exists in Kp13","1843 KP03526 does not exists in Kp13","2649 KP05119 does not exists in Kp13","2768 KP05321 does not exists in Kp13","3042 KP31595 does not exists in Kp13","3160 KP31992 does not exists in Kp13","3199 KP32179 does not exists in Kp13","3225 KP32375 does not exists in Kp13"],"properties":["hit_in_deg","homolog_to_mgh78578","total_pathogen","total_no_pathogen","overexpressed_in_polymyxin","overexpressed_in_polymixin_all_conditions","total_pathogen_norm","total_no_norm"],"formatedTimestamp":"07-10-2016 03:04:59"},{"uploader":"ezequieljsosa","timestamp":1494256906530,"errors":["189 KP32375 does not exists in Kp13","436 KP31595 does not exists in Kp13","971 KP02190 does not exists in Kp13","1293 KP01247 does not exists in Kp13","1540 KP32179 does not exists in Kp13"],"properties":["gut_offtarget"],"formatedTimestamp":"08-5-2017 03:21:46"},{"uploader":"ezequieljsosa","timestamp":1494257406095,"errors":["189 KP32375 does not exists in Kp13","436 KP31595 does not exists in Kp13","971 KP02190 does not exists in Kp13","1293 KP01247 does not exists in Kp13","1540 KP32179 does not exists in Kp13"],"properties":["gut_offtarget"],"formatedTimestamp":"08-5-2017 03:30:06"},{"uploader":"eze","timestamp":1495057168148,"errors":["280 KP31992 does not exists in Kp13","724 KP03526 does not exists in Kp13","1309 KP32375 does not exists in Kp13","1395 KP00701 does not exists in Kp13","1899 KP05119 does not exists in Kp13","2258 KP02777 does not exists in Kp13","2693 KP01728 does not exists in Kp13","2730 KP03837 does not exists in Kp13","2965 KP02190 does not exists in Kp13","3129 KP01083 does not exists in Kp13","3406 KP05614 does not exists in Kp13","3409 KP01079 does not exists in Kp13","3532 KP31560 does not exists in Kp13","3591 KP31595 does not exists in Kp13","3865 KP01247 does not exists in Kp13","4272 KP03061 does not exists in Kp13","4367 KP03205 does not exists in Kp13","4462 KP05321 does not exists in Kp13","4605 KP31604 does not exists in Kp13","4639 KP32179 does not exists in Kp13"],"properties":["gut_microbiome"],"formatedTimestamp":"17-5-2017 09:39:28"},{"uploader":"eze","timestamp":1495057729737,"errors":["280 KP31992 does not exists in Kp13","724 KP03526 does not exists in Kp13","1309 KP32375 does not exists in Kp13","1395 KP00701 does not exists in Kp13","1899 KP05119 does not exists in Kp13","2258 KP02777 does not exists in Kp13","2693 KP01728 does not exists in Kp13","2730 KP03837 does not exists in Kp13","2965 KP02190 does not exists in Kp13","3129 KP01083 does not exists in Kp13","3406 KP05614 does not exists in Kp13","3409 KP01079 does not exists in Kp13","3532 KP31560 does not exists in Kp13","3591 KP31595 does not exists in Kp13","3865 KP01247 does not exists in Kp13","4272 KP03061 does not exists in Kp13","4367 KP03205 does not exists in Kp13","4462 KP05321 does not exists in Kp13","4605 KP31604 does not exists in Kp13","4639 KP32179 does not exists in Kp13"],"properties":["gut_microbiome","gut_microbiome_norm"],"formatedTimestamp":"17-5-2017 09:48:49"},{"uploader":"eze","timestamp":1495058725647,"errors":[],"properties":["gut_microbiome","gut_microbiome_norm"],"formatedTimestamp":"17-5-2017 10:05:25"},{"uploader":"eze","timestamp":1495219757135,"errors":[],"properties":["human_offtarget"],"formatedTimestamp":"19-5-2017 06:49:17"},{"uploader":"eze","timestamp":1495221746962,"errors":[],"properties":["human_offtarget"],"formatedTimestamp":"19-5-2017 07:22:26"},{"uploader":"demo","timestamp":1518098143124,"errors":[],"properties":["essentiality"],"formatedTimestamp":"08-2-2018 01:55:43"},{"uploader":"demo","timestamp":1632424699481,"errors":[],"properties":["overexpression_in_carbapenem"],"formatedTimestamp":"23-9-2021 07:18:19"}],"refGenomeId":null,"proteomeId":null}